Humanity just made a weighty decision. On Friday, representatives of more than 60 nations, gathered in Versailles, France, approved a new definition for the kilogram. Since the 19th century, scientists have based their definition of the fundamental unit of mass on a physical object — a shining platinum iridium cylinder stored in a locked vault
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Since 1889, Le Grand K, a sleek cylinder of platinum-iridium metal, has ruled from its underground vault in Paris. An absolute monarch, it was the very definition of one kilogram of mass. Scientists from around the world made pilgrimages to it, bringing along their national kilogram standards to weigh in comparison. “The mother ship is
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Abstract Essential metabolic reactions are shaping constituents of metabolic networks, enabling viable and distinct phenotypes across diverse life forms. Here we analyse and compare modelling predictions of essential metabolic functions with experimental data and thereby identify core metabolic pathways in prokaryotes. Simulations of 15 manually curated genome-scale metabolic models were integrated with 36 large-scale gene
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Abstract Covalent modification of proteins by ubiquitin or ubiquitin chains is one of the most prevalent post-translational modifications in eukaryotes. Different types of ubiquitin chains are assumed to selectively signal respectively modified proteins for different fates. In support of this hypothesis, structural studies have shown that the eight possible ubiquitin dimers adopt different conformations. However,
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When ballots were tallied from Election Day last week, science-oriented candidates for U.S. Congress looked like real winners. Seven Democrats with degrees in science, technology, engineering, and medicine are headed to the House of Representatives; one won in the Senate. In addition, two Republicans with science backgrounds won House seats. The Democrats were endorsed by a
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Long intergenic noncoding RNAs (lincRNAs) have risen to prominence in cancer biology as new biomarkers of disease. Those lincRNAs transcribed from active cis-regulatory elements (enhancers) have provided mechanistic insight into cis-acting regulation; however, in the absence of an enhancer hallmark, computational prediction of cis-acting transcription of lincRNAs remains challenging. Here, University of Chicago researchers introduce
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The architectural design behind Japan’s new space research center is mind-boggling. The futuristic building will incorporate elements of spacecraft design, which emphasize light weight and high functionality. The whole thing will be suspended over a man-made, Moon-like crater. The building will be a robotics research center that’s part of the Avatar X space research campus on
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Every now and then, Earth’s protective magnetic cage changes its stripes, sending explosive showers of charged particles spilling into the atmosphere. NASA’s quartet of orbiting Magnetospheric Multiscale (MMS) satellites has finally recorded one in high detail on the planet’s night side, providing vital information on a phenomenon that stirs the winds of space throughout the
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Benefits of walking backwardsSetiadi Setiadi / EyeEm By Sam Wong To go back in time, it might help to go backwards in space. Volunteers in a study did better in a memory test if they walked backwards before taking it – or if they simply imagined moving backwards. Aleksandar Aksentijevic at the University of Roehampton,
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The Food and Drug Administration on Thursday announced a series of restrictions aimed at combating a growing public health menace — flavored e-cigarettes and tobacco products that have lured young people into vaping and smoking. And in a bold regulatory move, the agency said it would move to outlaw two traditional tobacco products that disproportionately
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PIWI-interacting RNAs: small RNAs with big functions PIWI-interacting RNAs: small RNAs with big functions, Published online: 16 November 2018; doi:10.1038/s41576-018-0073-3 PIWI-interacting RNAs (piRNAs) have numerous crucial biological roles, particularly transposon silencing in the germ line. In this Review, the authors describe our latest understanding of piRNA biogenesis and functions across diverse species, highlighting how, despite
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Antarctica’s Shackleton Ridge at sunset.NASA/John Sonntag It’s hard to imagine, but Antarctica wasn’t always covered in ice. This huge continental landmass, back in the age of the dinosaurs, was a lush forested landscape, teeming with large creatures and critters alike. Nowadays, shielded by the largest ice sheet on the planet, we are only beginning to
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Citation: Ebadi H, Perry M, Short K, Klemm K, Desplan C, Stadler PF, et al. (2018) Patterning the insect eye: From stochastic to deterministic mechanisms. PLoS Comput Biol 14(11): e1006363. https://doi.org/10.1371/journal.pcbi.1006363 Editor: Robert Johnston, Johns Hopkins University, UNITED STATES Received: March 23, 2017; Accepted: July 16, 2018; Published: November 15, 2018 Copyright: © 2018 Ebadi
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Citation: Frassl MA, Hamilton DP, Denfeld BA, de Eyto E, Hampton SE, Keller PS, et al. (2018) Ten simple rules for collaboratively writing a multi-authored paper. PLoS Comput Biol 14(11): e1006508. https://doi.org/10.1371/journal.pcbi.1006508 Editor: Fran Lewitter, Whitehead Institute, UNITED STATES Published: November 15, 2018 Copyright: © 2018 Frassl et al. This is an open access article
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Citation: Carvalho-Silva D, Garcia L, Morgan SL, Brooksbank C, Dunham I (2018) Ten simple rules for delivering live distance training in bioinformatics across the globe using webinars. PLoS Comput Biol 14(11): e1006419. https://doi.org/10.1371/journal.pcbi.1006419 Editor: Scott Markel, Dassault Systemes BIOVIA, UNITED STATES Published: November 15, 2018 Copyright: © 2018 Carvalho-Silva et al. This is an open
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WASHINGTON (Reuters – The U.S. Federal Communications Commission voted unanimously on Thursday to allow Tesla Inc (TSLA.O) Chief Executive Elon Musk’s Space X, Telesat Canada [PSPENC.UL] and two other companies to roll out new satellite-based broadband services. FILE PHOTO: Tesla and SpaceX CEO Elon Musk participates in a “fireside chat” at the National League of
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Share to facebook Share to twitter Share to linkedin Ocean wave under gray sky at daytime in Azores, PortugalSandro Kradolfer | Unsplash A study published earlier this month stating that the world’s oceans had absorbed up to 60% more heat than initially thought over the previous 25 years is being re-evaluated. Prior studies have measured ocean heat content using
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Most of us learn how to ride a bike during childhood. But as we grow older, many of us stop riding and put those once-beloved bikes in storage. Years later, when we discover these relics and hop on, it’s as if we never stopped biking. This is surprising because our memories let us down in
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The analysis of transcriptome data from non-model organisms contributes to our understanding of diverse aspects of evolutionary biology, including developmental processes, speciation, adaptation, and extinction. Underlying this diversity is one shared feature, the generation of enormous amounts of sequence data. Data availability requirements in most journals oblige researchers to make their raw transcriptome data publicly
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At the London Restaurant Festival, Sebastian Valouch is looking very slightly on edge. “I know the technology works,” he says. “But demonstrations always make you feel a little nervous.” He is talking about the latest innovation from his employer, the BASF subsidiary company trinamiX GmbH. It’s a prototype handheld spectrometer, a point-and-click device that can
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Neural nets supplant marker genes in analyzing single cell RNA sequencing | RNA-Seq Blog Don’t Miss Posted by: RNA-Seq Blog in Commentary 13 hours ago 302 Views CMU’s scQuery Web Server Uses New Method To Determine Cell Types, Identify Key Genes Computer scientists at Carnegie Mellon University say neural networks and supervised machine learning techniques
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