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It’s one thing to eat chicken every day. It’s something else to have that on your permanent record, as in the geological record, the remnants of our time that archaeologists or aliens of the future will sift through to determine who we were and how we shaped our world. But a group of scientists argue
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Researchers may choose, for a number of reasons, to sequence a given individual more than once. Regardless of intent, it is important to identify potentially mislabeled or contaminated samples before using the data (e.g. merging the data from replicate sequence runs or using the data to optimize bioinformatics quality filters). Unfortunately, existing methods to detect
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Polymer–drug conjugate therapeutics: advances, insights and prospects Polymer–drug conjugate therapeutics: advances, insights and prospects, Published online: 12 December 2018; doi:10.1038/s41573-018-0005-0 The conjugation of therapeutic agents to polymer carriers, such as polyethylene glycol (PEG), can control drug delivery, enhance solubilization, increase efficacy and improve pharmacokinetics. Here, Grinstaff, Colson and Ekladious discuss recent advances in the preclinical
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Annie Jump Cannon shared the experience of being deaf with her colleague Henrietta Leavitt.Smithsonian Institution https://www.flickr.com/photos/25053835@N03/3322793868/ December 11 is the birthday of astronomer Annie Jump Cannon, who developed the system astronomers use to classify stars. But the most famous female astronomer in history almost abandoned her scientific career before it started. Astronomers classify stars based
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Abstract Protein-DNA interactions play important roles in regulations of many vital cellular processes, including transcription, translation, DNA replication and recombination. Sequence variants occurring in these DNA binding proteins that alter protein-DNA interactions may cause significant perturbations or complete abolishment of function, potentially leading to diseases. Developing a mechanistic understanding of impacts of variants on protein-DNA
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Combining various features or fusing various features can usually lead to high-accuracy models [52–58]. We have n features for lncRNAs (or proteins), denoted as n feature matrices , and have m types of similarities for lncRNAs (or proteins), denoted as m similarity matrices . The predicted lncRNA-protein interaction matrix is denoted as R. The known
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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There is a gradual change afoot at fuel forecourts in several markets, whether developed or developing, being led by none other than the refining and marketing units of energy behemoths, including the top 20 international oil and gas companies ranked by market capitalization – that’s the increasing visibility of electric vehicle (EV) charging points. In Europe, much
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Want climate news in your inbox? Sign up here for Climate Fwd:, our email newsletter. Persistent warming in the Arctic is pushing the region into “uncharted territory” and increasingly affecting the continental United States, scientists said Tuesday. “We’re seeing this continued increase of warmth pervading across the entire Arctic system,” said Emily Osborne, an official
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Posted by: RNA-Seq Blog in Publications, Quality Control 5 hours ago 85 Views Next-generation sequencing (NGS) techniques have been used to generate various molecular maps including genomes, epigenomes, and transcriptomes. Transcriptomes from a given cell population can be profiled via RNA-seq. However, there is no simple way to assess the characteristics of RNA-seq data systematically.
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Cellecta, Inc. today announced the launch of five DriverMap™ Predesigned RNA-Seq Panels. Each panel measures expression levels of over 1200 expertly curated essential genes selected from publications, open access databases, and other resources. DriverMap Predesigned RNA-Seq Panels target known genes responsible for disease, drug response, immune response and related phenotypes. DriverMap™ Predesigned Panels use the
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A drought scorched the Great Plains, causing wildfires and US$2.5 billion in agriculture losses. Catastrophic floods submerged more than a third of Bangladesh. Record-shattering heat waves killed scores of people in Europe and China. These were among 15 extreme weather events in 2017 that were made more likely by human-cased climate change, according to in-depth
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This mosaic image of asteroid Bennu, composed of 12 PolyCam images collected on December 2, 2018 by the OSIRIS-REx spacecraft from a range of 15 miles (24 km). NASA/Goddard/University of Arizona/Handout via REUTERS ORLANDO, Fla. (Reuters) – NASA’s OSIRIS-REx spacecraft has discovered ingredients for water on a relatively nearby skyscraper-sized asteroid, a rocky acorn-shaped object
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Nelly Sachs received the Nobel Prize for Literature on her birthday in 1966.Google Monday’s Google Doodle honors poet and playwright Nelly Sachs, who escaped from Nazi Germany in 1940 and gave a voice to the horrors of the Holocaust and the struggle to live in its aftermath. Born in 1891, Nelly Sachs enjoyed a sheltered,
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A recent report about a prominent academic investigator who failed to disclose millions of dollars in personal income from corporate relationships highlights the degree to which the system to manage, reduce, or eliminate financial conflicts of interest (COIs) in biomedical research remains inadequate.1 The story quoted the individual as stating that his disclosure lapses were
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A bedside diagnostic approach is needed for mechanically ventilated patients in intensive care who develop new pulmonary infiltrates on chest x-ray and have a differential diagnosis of pneumonia. These patients are regularly given broad-spectrum antibiotics before bacteria culture results are ready, which contributes to overtreatment and antibiotic resistance. In addition, commonly used sampling methods like
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The World Medical Association developed the Declaration of Helsinki as a statement regarding ethical principles for medical research involving human research participants and directs physicians to promote and safeguard the health, well-being, and rights of patients. Included in this declaration is the requirement that each potential research participant be informed of possible conflicts of interest
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