Month: October 2018

Genetics research offers both potential benefits and potential harms to under-represented communities. While researchers have been making great strides in the use of genomics for both medical and historical questions, the vast majority of participants in such studies are of European descent.  This is due to several reasons, among them a history of colonialism and exploitation
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Image Want climate news in your inbox? Sign up here for Climate Fwd:, our email newsletter. WASHINGTON — Ryan Zinke, the interior secretary, faces at least a half-dozen ongoing ethics inquiries related to his leadership at the Interior Department. The inquiries include investigations into Mr. Zinke’s personal financial dealings and his handling of policy matters
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Citation: Nöh K, Niedenführ S, Beyß M, Wiechert W (2018) A Pareto approach to resolve the conflict between information gain and experimental costs: Multiple-criteria design of carbon labeling experiments. PLoS Comput Biol 14(10): e1006533. https://doi.org/10.1371/journal.pcbi.1006533 Editor: Vassily Hatzimanikatis, Ecole Polytechnique Fédérale de Lausanne, SWITZERLAND Received: May 16, 2018; Accepted: September 27, 2018; Published: October 31,
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Abstract Effective cancer treatment is crucially dependent on the identification of the biological processes that drive a tumor. However, multiple processes may be active simultaneously in a tumor. Clustering is inherently unsuitable to this task as it assigns a tumor to a single cluster. In addition, the wide availability of multiple data types per tumor
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Abstract Malaria is a life-threatening disease spread by mosquitoes. Plasmodium falciparum M1 alanyl aminopeptidase (PfM1-AAP) is a promising target for the treatment of malaria. The recently solved crystal structures of PfM1-AAP revealed that the buried active site can be accessed through two channel openings: a short N-terminal channel with the length of 8 Å and
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Sebastian Tobler’s doctors thought his legs would never move again after a mountain-biking accident completely paralyzed them. When he signed up for a study at Lausanne University Hospital in Switzerland, Tobler’s injury was so severe that the researchers had doubts their experimental treatment would work. “I was like, should we enroll this participant? It’s very
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“Telemedicine is the natural evolution of healthcare in the digital world,” American Telemedicine Association. Telemedicine empowers the caregivers to remotely interact with their patients, which greatly improves both the efficiency and affordability of healthcare. Today patients, doctors and caregivers have learned to accept telemedicine (often called ‘telehealth’ or ‘connected health’) as one of many ways
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SEATTLE/ORLANDO, Fla. (Reuters) – SpaceX Chief Executive Officer Elon Musk flew to the Seattle area in June for meetings with engineers leading a satellite launch project crucial to his space company’s growth. FILE PHOTO: SpaceX headquarters is shown in Hawthorne, California, U.S. September 19, 2018. REUTERS/Mike Blake/File Photo Within hours of landing, Musk had fired
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Posted by: RNA-Seq Blog in Review Publications 6 hours ago 116 Views Transcriptome profiling has become routine in studies of many biological processes. However, favored approaches such as short-read Illumina RNA sequencing are giving way to long-read sequencing platforms better suited to interrogating the complex transcriptomes typical of many RNA and DNA viruses. Here, researchers
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Just in time for Halloween, astronomers have delivered the best-yet view of a real-life cosmic monster—Sagittarius A*, a supermassive black hole lurking at the center of the Milky Way. Or, rather, a view of hot clumps of gas that orbit it, teetering on the edge of oblivion. The results reveal new, previously unknown properties of
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Analysis for Relapse-Specific Mutations To determine whether AML relapse after transplantation was associated with recurrent mutations, we performed enhanced exome sequencing on samples from 15 patients who had a relapse after transplantation, including 6 patients who presented with isolated extramedullary disease. The transplants had been from HLA-matched related donors, HLA-matched unrelated donors, or HLA-mismatched unrelated
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To the Editor We thank Kao et al. (June 21 issue)1 for their discussion but question the diagnosis of atypical hemolytic–uremic syndrome, a disorder we similarly considered in a 3-year-old girl who presented with anemia (hemoglobin level, 78 g per deciliter), thrombocytopenia (platelet count, 22,000 per cubic millimeter), and azotemia (creatinine level, 1.9 mg per
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Abstract Background The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces tumor-cell phagocytosis. 5F9 synergizes with rituximab to eliminate B-cell non-Hodgkin’s lymphoma cells by enhancing macrophage-mediated antibody-dependent cellular phagocytosis. This combination was evaluated clinically. Methods We conducted a phase 1b study involving patients with relapsed or refractory non-Hodgkin’s lymphoma.
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Abstract Background A point-prevalence survey that was conducted in the United States in 2011 showed that 4% of hospitalized patients had a health care–associated infection. We repeated the survey in 2015 to assess changes in the prevalence of health care–associated infections during a period of national attention to the prevention of such infections. Methods At
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To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to represent a previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac
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The Soyuz rocket is launched with Expedition 57 Flight Engineer Nick Hague of NASA and Flight Engineer Alexey Ovchinin of Roscosmos at the Baikonur Cosmodrome, Kazakhstan October 11, 2018. NASA/Bill Ingalls/Handout via REUTERS MOSCOW (Reuters) – The Soyuz rocket launch failure this month was caused by a faulty sensor, Russian news agencies reported citing an
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Posted by: RNA-Seq Blog in Publications 56 mins ago 35 Views Cancers acquire resistance to systemic treatment with platinum-based chemotherapy (eg, cisplatin [CDDP]) as a result of a dynamic intratumoral heterogeneity (ITH) and clonal repopulation. However, little is known about the influence of chemotherapy on ITH at the single-cell level. Here, mapping the transcriptome of
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Kepler, NASA’s vaunted planet-hunting space telescope, has run out of maneuvering fuel and is being retired, the space agency announced on Tuesday. After nine and a half years in orbit, 530,506 stars observed and 2,662 planets discovered around other stars, the little spacecraft will be left to drift forever around the sun. Astronomers mourned the
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NASA announced Tuesday that Kepler, an orbital telescope that’s been spotting and analyzing distant planets for the past nine years, has run out of fuel and will no longer carry out scientific research. Since it launched in March 2009, the telescope identified over 2,600 planets outside of our solar system, and found that as much
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This illustration made available by NASA shows the Kepler Space Telescope. As of October 2018, the planet-hunting spacecraft has been in space for nearly a decade. (NASA via AP) The Kepler Space Telescope has run out of fuel and ended its 9.5-year career, just days after astronomers announced possible evidence of a moon orbiting an
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Want climate news in your inbox? Sign up here for Climate Fwd:, our email newsletter. WASHINGTON — The Interior Department’s top watchdog has referred an investigation into a possible conflict of interest by Interior Secretary Ryan Zinke to the Justice Department, according to a person familiar with the matter, a sign that the federal government
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Abstract The gut microbiota represent a highly complex ecosystem comprised of approximately 1000 species that forms a mutualistic relationship with the human host. A critical attribute of the microbiota is high species diversity, which provides system robustness through overlapping and redundant metabolic capabilities. The gradual loss of bacterial diversity has been associated with a broad
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Abstract Chemical-genetic interactions–observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes–contain rich functional information linking compounds to their cellular modes of action. To systematically identify these interactions, an array of mutants is challenged with a compound and monitored for fitness defects, generating a chemical-genetic interaction profile that provides a quantitative, unbiased
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Fine-art handler Tom Richardson poses with a jacket belonging to British theoretical physicist Stephen Hawking ahead of an auction of items from Hawkings’ personal estate at Christie’s in London, Britain October 30, 2018. REUTERS/Toby Melville LONDON (Reuters) – From a copy of his PhD thesis to his wheelchair, items belonging to Stephen Hawking are headed
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For voters around the world, including the millions of Americans who will cast ballots in the midterms up to and on November 6, an election is democracy in action—an opportunity to make their voices heard, have a say in how their government is run and, if necessary, throw the bums out. It is a thoroughly
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Single cell transcriptomics is critical for understanding cellular heterogeneity and identification of novel cell types. Leveraging the recent advances in single cell RNA sequencing (scRNA-Seq) technology requires novel unsupervised clustering algorithms that are robust to high levels of technical and biological noise and scale to datasets of millions of cells. University of Connecticut researchers present
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