Month: December 2018

(Reuters) – Three-time NBA champion Stephen Curry will take space agency NASA up on its offer to tour its lunar lab after he sparked controversy by saying he did not believe humans had ever been to the Moon, comments he later called a joke. FILE PHOTO: Dec 5, 2018; Cleveland, OH, USA; Golden State Warriors
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Scattered among your genes like old recipes in an heirloom cookbook are DNA sequences that once helped Neanderthals survive. The codes that contributed to the construction of our extinct cousin’s ever-so-slightly elongated skulls could still be at work in some modern humans, affecting neurological development and pushing their craniums into a slightly different shape. Neanderthals
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Abstract G-quadruplexes are non-canonical nucleic-acid structures that control transcription, replication, and recombination in organisms. G-quadruplexes are present in eukaryotes, prokaryotes, and viruses. In the latter, mounting evidence indicates their key biological activity. Since data on viruses are scattered, we here present a comprehensive analysis of potential quadruplex-forming sequences (PQS) in the genome of all known
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Abstract Next generation sequencing of viral populations has advanced our understanding of viral population dynamics, the development of drug resistance, and escape from host immune responses. Many applications require complete gene sequences, which can be impossible to reconstruct from short reads. HIV env, the protein of interest for HIV vaccine studies, is exceptionally challenging for
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The seeds of Alzheimer’s disease may have been transmitted along with human growth hormone into eight British patients treated decades ago, according to a study published Thursday in Nature. If supported by further research, the findings imply Alzheimer’s could potentially be transmitted via close contact with the brain tissue of someone who has the disease.
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Basic lab equipment can produce minuscule 3D-printed objectsEd Boyden and colleagues By Douglas Heaven Making miniscule objects is hard – far easier to make bigger things and then shrink them. That’s the idea behind a 3D printing technique called implosion fabrication. The method can be used to produce a variety of shapes, from tiny hollow spheres
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On April 30, the Pu‘u ‘O‘o crater on Hawaii’s Kilauea volcano, suddenly collapsed. It was the starting point for the volcano’s monthslong eruption, which went on to produce 320,000 Olympic-sized swimming pools’ worth of lava that transformed the landscape and ultimately destroyed 700 homes. Now the U.S. Geological Survey’s Hawaiian Volcano Observatory and other scientists
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This article has no abstract; the first 100 words appear below. The mitral valve is a complex structure encompassing the valve leaflets, annulus, chordae tendineae, and papillary muscles.1 Primary mitral regurgitation is caused by a primary leaflet abnormality, whereas secondary mitral regurgitation occurs when structurally normal valve leaflets are unable to coapt completely owing to
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A 67-year-old woman presented to the emergency department with a 6-week history of progressive exertional dyspnea. Her medical history was notable for lung transplantation that had been performed 8 years earlier. Immunosuppressive medications included mycophenolate mofetil and tacrolimus. Laboratory studies showed normocytic anemia, with a hemoglobin level of 6.9 g per deciliter (reference range, 11.9
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This article has no abstract; the first 100 words appear below. To the Editor: Duncavage and colleagues (Sept. 13 issue)1 address the molecular predictors of disease progression and survival among patients with myelodysplastic syndrome (MDS) who underwent allogeneic hematopoietic stem-cell transplantation. With the use of enhanced exome sequencing, they found that detection of at least
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Researchers from Fondazione Bruno Kessler introduce the CDRP (Concatenated Diagnostic-Relapse Prognostic) architecture for multi-task deep learning that incorporates a clinical algorithm, e.g., a risk stratification schema to improve prognostic profiling. They present the first application to survival prediction in High-Risk (HR) Neuroblastoma from transcriptomics data, a task that studies from the MAQC consortium have shown
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Deciphering bacterial epigenomes using modern sequencing technologies Deciphering bacterial epigenomes using modern sequencing technologies, Published online: 13 December 2018; doi:10.1038/s41576-018-0081-3 DNA methylation is the primary epigenetic modification in bacteria, but a lack of suitable methods has hampered its study. Now, new sequencing technologies, including single-molecule, real-time sequencing and nanopore sequencing, are providing new opportunities for
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Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine, Published online: 13 December 2018; doi:10.1038/s41580-018-0086-y The Hippo pathway effectors YAP and TAZ regulate normal and tumorigenic organ growth. Recent studies in vitro and in mouse models have shown that these two transcription co-activators can also promote tissue regeneration.
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People who experience the pain and disfigurement of eczema (aka atopic dermatitis, AD) already have to contend with cracked skin, rashes, weeping sores, and endless itching. But that’s not all. New research examining the “profound psychosocial burden” shouldered by people with AD shows they’re not just at greater risk of depression; having the skin condition
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Should the government pay for medical research that uses tissue from aborted fetuses? This debate, ever smoldering, has erupted again, pitting anti-abortion forces in the Trump administration against scientists who say the tissue is essential for studies that benefit millions of patients. In a letter last week that read like a shot across the bow,
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