Month: December 2018

ORLANDO, Fla. (Reuters) – A NASA explorer is on track to reach the solar system’s outermost region by early Tuesday morning, when scientists expect it to fly by a space rock 20 miles long and billions of miles from Earth, the most distant close encounter of its kind. FILE PHOTO: An artist’s impression of NASA’s
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Abstract Selective brain responses to objects arise within a few hundreds of milliseconds of neural processing, suggesting that visual object recognition is mediated by rapid feed-forward activations. Yet disruption of neural responses in early visual cortex beyond feed-forward processing stages affects object recognition performance. Here, we unite these discrepant findings by reporting that object recognition
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Abstract Protein Direct Coupling Analysis (DCA), which predicts residue-residue contacts based on covarying positions within a multiple sequence alignment, has been remarkably effective. This suggests that there is more to learn from sequence correlations than is generally assumed, and calls for deeper investigations into DCA and perhaps into other types of correlations. Here we describe
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Key descriptive characteristics of participants at baseline are shown in Table 1. Short time interval follow-up study We tested 61 participants at baseline, and then after an interval of 6 months (Fig 1), using the task briefly described above (and fully in Methods; very similar to [26]). We thus first explored temporal individual stability and
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Citation: Tan ZW, Guarnera E, Berezovsky IN (2018) Exploring chromatin hierarchical organization via Markov State Modelling. PLoS Comput Biol 14(12): e1006686. https://doi.org/10.1371/journal.pcbi.1006686 Editor: Marc A. Marti-Renom, CNAG – Centre Nacional d’Anàlisi Genòmica and CRG – Centre de Regulació Genòmica, SPAIN Received: May 15, 2018; Accepted: November 27, 2018; Published: December 31, 2018 Copyright: © 2018
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Citation: Cokol M, Li C, Chandrasekaran S (2018) Chemogenomic model identifies synergistic drug combinations robust to the pathogen microenvironment. PLoS Comput Biol 14(12): e1006677. https://doi.org/10.1371/journal.pcbi.1006677 Editor: Peter M. Kasson, University of Virginia, UNITED STATES Received: May 15, 2018; Accepted: November 27, 2018; Published: December 31, 2018 Copyright: © 2018 Cokol et al. This is an
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Ancient city of Yaxchilan hidden in the jungle in the borderland of Mexico and GuatemalaGetty “With just one profound discovery, mankind’s entire story could change,” so said Megan Fox in the Travel Channel’s latest archaeology-themed television show, Legends of the Lost. This statement presents an excellent example of the two-sided conundrum facing attempts to bring
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It’s a common misconception that hangovers are mainly the result of dehydration. An evening of heavy drinking can lead to inflammation of the stomach and intestines, poor-quality sleep and the production of toxic substances that lead to vomiting, sweating and an increased heart rate. Research also suggests that hangovers can hamper the ability to concentrate
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Posted by: RNA-Seq Blog in Workflow 3 hours ago 78 Views Optically decodable beads link the identity of a sample to a measurement through an optical barcode, enabling libraries of biomolecules to be captured on beads in solution and decoded by fluorescence. This approach has been foundational to microarray, sequencing, and flow-based expression profiling technologies.
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Enlarge this image Researchers say human brains can become overwhelmed by cute traits, such as large eyes and small noses, embodied by movie characters like Bambi. Disney Junior/Disney Channel via Getty Images hide caption toggle caption Disney Junior/Disney Channel via Getty Images The holiday season is all about cute. You’ve got those ads with adorable
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There’s something beautiful in deciding how one’s final moments should be confined to the memory of our loved ones. Advances in technology and changing mindsets seem to have people wondering why a coffin in the ground should have to be the only option of final resting place. Residents in Washington state have a brand new
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Insilico Medicine, a Rockville-based company developing the end-to-end drug discovery pipeline utilizing the next generation artificial intelligence, will present its latest results in modern and next-generation AI for Drug Discovery at The Longevity Therapeutics 2019 in San Francisco, 30 of January. Artificial Intelligence (AI) techniques, such as deep learning (DL), reinforcement learning (RL), and generative
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Functional Magnetic Resonance Imaging (fMRI) [1, 2] provides a novel perspective for the study of brain functions, which is noninvasive and has high resolution in both space and time. Different from task-based fMRI [3, 4] that studies the brain reacting to stimulus, resting state fMRI [5, 6] studies the inner functional connectivity of brain, which
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We downloaded the MHC-I peptide datasets from the IEDB [48]. We filtered, processed, and prepared the data according to the guidelines in Vang’s work [10]. The amount of highly-binding-affinity peptides of different allele subtypes varies substantially. The 9-mer peptides of HLA-A*0201 are 13,088 while the 9-mer peptides for HLA-A*0206, HLA-B*2705, HLA-A*6802, and Mamu-A1*001:01 are only
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Cyclic peptides have attracted considerable interest from both the pharmaceutical industry and academia [1–4] for three main reasons. First, as with monoclonal antibody therapeutics, they can bind to target proteins with high affinities [5]. Second, they can interact with flat, shallow, and featureless surfaces of proteins or protein-protein interaction interfaces that are barely targeted by
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Protein sequence alignments, as an effective and intuitive way of identifying homologous regions among sequences, play a fundamental role in various biomedical researches such as database construction and query, prediction of protein structure and function, etc. [1]. Protein sequence alignments could identify regions of similarity that may reflect biological relationships among the input sequences. As
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Low-cost metagenomic and amplicon-based sequencing has provided a snapshots of microbial communities and their surrounding environments. One of the goals for case-control studies using microbiome data is to investigate whether cases differ from controls in term of the microbiome composition of a particular body ecosystems (e.g., the gut) and which taxa are responsible for any
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Publication date: Available online 26 October 2018 Source: Methods Author(s): Hussain Jinnah, Randi J. Ulbricht Abstract The deamination of adenosine to inosine by RNA editing is a widespread post-transcriptional process that expands genetic diversity. Selective substitution of inosine for adenosine in pre-mRNA transcripts can alter splicing, mRNA stability, and the amino acid sequence of the
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When you look at this picture, what do you assume? What are the hidden dangers of those assumptions?CC0 Creative Commons Science is all about questions. Questions, questions, questions. We constantly interrogate nature, trying to reveal some closely-held secrets. Over the course of years, decades, and centuries, we learn to ask ever-more sophisticated questions. Building on
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Axel Bueckert/EyeEm/Getty By Alice Klein Bread and pasta may be back on the menu for people with coeliac disease participating in a clinical trial next year. Coeliac disease makes you unable to eat foods containing gluten without experiencing an immune reaction that damages your gut and can cause vomiting, diarrhoea and fatigue. A vaccine called
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Mining corporation Rio Tinto says that an autonomous rail system called AutoHaul that it’s been developing in the remote Pilbara region of Australia for several years is now entirely operational — an accomplishment the company says makes the system the “world’s largest robot.” “It’s been a challenging journey to automate a rail network of this size and scale in
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From monkey markets to fishy business, we’re finding that many animals make rational trades. Even brainless fungi have a thing or two to teach us Clean your scales, guv’nor? Cleaner wrasse operate according to savvy economic principlesMedia Drum World/Alamy By Daniel Cossins “THE propensity to truck, barter and exchange one thing for another… is common
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The must-read brain books of 2018 featured perception, emotion, hormones, psychedelics, culture, time, technology, addiction, and the biological roots of consciousness. The eight books on this list all reveal important, timely insights about who we are, what we do and why we do it. This is part one of a two-part list; the second installment
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Adam and Eve might have managed it in the Bible, but scientifically speaking, would two people be enough to repopulate our world from scratch, despite the inevitable health issues associated with inbreeding and a limited gene pool?  First of all, let’s deal with the obvious problems. The first ‘new’ generation would obviously all be brothers and
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Share to facebook Share to twitter Share to linkedin RB Health (Canada) is recalling specific batches of Durex Real Feel® Extra Lubricated 10ct condoms and Durex Real Feel ® 20ct condoms after samples failed to pass shelf-life durability tests. (Photo: Getty Images)Getty These condoms may not be able to handle you. But sorry, it has nothing to do with you.
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Enlarge this image Indonesian Navy personnel watch as Anak Krakatau spews volcanic materials into the waters of Indonesia’s Sunda Strait this week. Fauzy Chaniago/AP hide caption toggle caption Fauzy Chaniago/AP An undersea earthquake occurred Saturday off the coast of the southern Philippines. The U.S. Geological Survey says it struck at a depth of about 38
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Bacteria are slippery little suckers. They evolve rapidly, developing resistance to antibiotics and therefore becoming increasingly difficult to deal with. For the first time, researchers in 2018 caught on film one of the mechanisms the microbes use for this speedy evolution. Two Vibrio cholerae bacteria – the pathogen responsible for cholera – sit under a
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Caltech/MIT/LIGO Laboratory By Leah Crane The hunt for gravitational waves is back on. After a little over a year of upgrades, the Laser Interferometer Gravitational-Wave Observatory (LIGO) is preparing for its third run of observations. Gravitational waves are ripples in space-time that emanate from massive objects as they move, and that stretch and squeeze everything
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