Month: January 2019

Abstract The circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of circadian rhythms to changing external conditions, however, has yet to be clearly elucidated. We explored the mechanism of action of nicotinamide in
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Citation: Marković D, Reiter AMF, Kiebel SJ (2019) Predicting change: Approximate inference under explicit representation of temporal structure in changing environments. PLoS Comput Biol 15(1): e1006707. https://doi.org/10.1371/journal.pcbi.1006707 Editor: Jill O’Reilly, Oxford University, UNITED KINGDOM Received: April 8, 2018; Accepted: December 11, 2018; Published: January 31, 2019 Copyright: © 2019 Marković et al. This is an
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HumanityPexels.com The next big tech trend is humanity, was a big theme coming out of the World Government Summit in Dubai in February 2018, delivered by an all-star cast including Narendra Modi, Christine Lagard, Malcolm Gladwell and will.i.am. I found it very refreshing despite being the only “adult supervision” on a cryptocurrency panel talking about
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To evaluate the effect of 100 mV/mm of EStim on the osteogenic differentiation of MSCs, cells treated with EStim for 3, 7, and 14 days or nontreated (control) were analyzed at day 14 of culturing by assessing morphological changes and calcium deposition (Figure 2). This was done by imaging cells using bright-field microscopy (morphology changes)
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Artificial intelligence can play chess, drive a car and diagnose medical issues. Examples include Google DeepMind’s AlphaGo, Tesla’s self-driving vehicles, and IBM’s Watson. This type of artificial intelligence is referred to as Artificial Narrow Intelligence (ANI) – non-human systems that can perform a specific task. We encounter this type on a daily basis, and its
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RNA-seq is widely used for transcriptomic profiling, but the bioinformatics analysis of resultant data can be time-consuming and challenging, especially for biologists. Researchers at South Dakota State University aimed to streamline the bioinformatic analyses of gene-level data by developing a user-friendly, interactive web application for exploratory data analysis, differential expression, and pathway analysis. iDEP (integrated
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The photo above is not depicting some ten-legged mutant bird as some of our Instagram commenters have suggested. It’s also not one of those hilarious birds with arms memes. He’s just one brave daddy bird hauling his four chicklings to safety. Comb-crested Jacanas (Irediparra gallinacea) are also known as lillytrotters or Jesus-birds for their ability to
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Exploring cellular responses to stimuli using extensive gene expression profiles has become a routine procedure performed on a daily basis. Raw and processed data from these studies are available on public databases but the opportunity to fully exploit such rich datasets is limited due to the large heterogeneity of data formats. In recent years, several
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Since its discovery in 1938, the drug LSD — that’s lysergic acid diethylamide — has puzzled researchers. They knew the drug had a profound effect on people, causing hallucinations and an altered state of consciousness, but they couldn’t figure out why. Now that could be changing. A research team from the University Hospital of Psychiatry Zurich thinks it’s figured out
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The fact of the matter is I don’t know exactly how cold it got at my house today. The mercury thermometer on our porch only goes down to -30 degrees Fahrenheit (-34.4 Celsius). The digital thermometer in our backyard weather station bottoms out at -40 Fahrenheit (-40 Celsius). For roughly two hours on Wednesday this
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It has been one of the most pressing unanswered questions in public health: Do e-cigarettes actually help smokers quit? Now, the first, large rigorous assessment offers an unequivocal answer: yes. The study, published Wednesday in the New England Journal of Medicine, found that e-cigarettes were nearly twice as effective as conventional nicotine replacement products, like
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1. Reck M, Heigener DF, Mok T, Soria JC, Rabe KF. Management of non-small-cell lung cancer: recent developments. Lancet. 2013;382:709–19. 2. Oltean S, Bates DO. Hallmarks of alternative splicing in cancer. Oncogene. 2014;33:5311–8. 3. David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev. 2010;24:2343–64. 4. Wahl MC, Will
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Simulation model CERONCO is a predominantly discrete multiscale computational model of cervical cancer response to treatment (external beam radiotherapy with concomitant weekly cisplatin, followed by pulsed dose rate brachytherapy) in the patient-individualized context. It makes use of the available multiscale (e.g. imaging, histological, treatment) longitudinal data of the patient. CERONCO follows a cellular automaton approach.
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Architecture of the LCM For the reader’s convenience, we introduce the structure of the LCM (see Fig. 1). The LCM represents a small region in the visual cortex of the cat as a sheet of cortical columns, within which neuron groups are situated (see Methods and Fig. 1B). Neuronal dynamics are modelled using a ‘mean field approximation’
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The advent of high throughput sequencing technologies has greatly accelerated the identification of variants that underlie Mendelian and complex diseases [1–7]. With the cost of sequencing decreasing and sequencing accuracy improving, an increasing number of research laboratories/projects have adopted these technologies to interrogate variants from a few or even hundreds to thousands of human samples
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New technologies for analyzing the three-dimensional chromosome organization in a genome-wide manner have revealed mechanisms by which chromosome communication is established [1]. By using different types of high-throughput techniques, such as ChIP-sequencing sensitive for different types of histone modifications, whole genome bisulfite sequencing, ATAC-sequencing, and DNase-Seq, many studies have discovered a large number of enhancers
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Synthetic data In this section, we examine the performance of MuClone on simulated data. In what follows, we generate N loci from M samples with K underlying tumour mutation clusters with sequencing error rate (epsilon) and tumour content tm. We first randomly generate an evolutionary relationship between clusters, viewed as a binary phylogenetic tree. Each
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The FNIH Biomarkers Consortium embraces the BEST The FNIH Biomarkers Consortium embraces the BEST, Published online: 31 January 2019; doi:10.1038/d41573-019-00015-w The Biomarkers Consortium aims to facilitate drug development with biomarkers across a range of diseases. Here, we briefly highlight its accomplishments so far and its recent expansion in scope to include related tools along the
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PPAR-δ agonists dataset Agonists (789) were collected from different literature sources including CHEMBL29 and WOMBAT30. The range of their agonist activities (EC50) was 0.03–1000 nM. Figures S1–S3 present some characteristics of those 789 PPAR-δ agonists. They partially obey Lipinski’s Rule of Five (ROF) for Oral availability of drugs31 and Oprea’s rules for “Lead like molecules”30 (63% and
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Vaping can help some people stop smoking cigarettesGuy Corbishley / Alamy By Clare Wilson Vaping really does appear to help people stop smoking better than old-style nicotine patches and gum. Quit rates were nearly twice as high in people who switched to e-cigarettes than in those who used other nicotine-replacement therapies in a recent trial. E-cigarettes
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Citation: Clark JJ, Benson ML, Smith RD, Carlson HA (2019) Inherent versus induced protein flexibility: Comparisons within and between apo and holo structures. PLoS Comput Biol 15(1): e1006705. https://doi.org/10.1371/journal.pcbi.1006705 Editor: Charlotte M. Deane, University of Oxford, UNITED KINGDOM Received: July 3, 2018; Accepted: December 7, 2018; Published: January 30, 2019 Copyright: © 2019 Clark et
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Abstract Gut microbiota and human relationships are strictly connected to each other. What we eat reflects our body-mind connection and synchronizes with people around us. However, how this impacts on gut microbiota and, conversely, how gut bacteria influence our dietary behaviors has not been explored yet. To quantify the complex dynamics of this interplay between
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