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Researchers in Japan think they have found an answer to the fundamental biological question of how individual cells know which way to position themselves within a complex, multicellular body. Depending on a cell’s purpose in the larger structure, contact or diffuse chemical signals direct it to its final destination. The journey from egg and sperm
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A team of biologists, physicists and mathematical modellers in Cambridge have studied the genetic activity of over 100,000 embryonic cells to establish the molecular blueprint of mouse early embryo development. This new research provides fundamentally important information on how mammalian embryos develop during gastrulation, a key stage of development, and paves the way for new
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A careful re-analysis of data taken at the Department of Energy’s Thomas Jefferson National Accelerator Facility has revealed a possible link between correlated protons and neutrons in the nucleus and a 35-year-old mystery. The data have led to the extraction of a universal function that describes the EMC Effect, the once-shocking discovery that quarks inside
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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Scientists have discovered tadpole-shaped jets coming out of regions with intense magnetic fields on the Sun. Unlike those living on Earth, these “tadpoles” — formally called pseudo-shocks — are made entirely of plasma, the electrically conducting material made of charged particles that account for an estimated 99 percent of the observable universe. The discovery adds
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Long before Snapchat, Instagram, Facebook and even MySpace, early Mississippian Mound cultures in America’s southern Appalachian Mountains shared artistic trends and technologies across regional networks that functioned in similar ways as modern social media, suggests new research from Washington University in St. Louis. “Just as we have our own networks of ‘friends’ and ‘followers’ on
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In the quest to design more efficient solar cells and light-emitting diodes (LEDs), a team of engineers has analyzed different types of defects in the semiconductor material that enables such devices to determine if and how they affect performance. Rohan Mishra, assistant professor of mechanical engineering & materials science in the McKelvey School of Engineering
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A new type of light-emitting diode lightbulb could one day light homes and reduce power bills, according to Penn State researchers who suggest that LEDs made with firefly-mimicking structures could improve efficiency. “LED lightbulbs play a key role in clean energy,” said Stuart (Shizhuo) Yin, professor of electrical engineering. “Overall commercial LED efficiency is currently
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Excavations at two quarries in Wales, known to be the source of the Stonehenge ‘bluestones’, provide new evidence of megalith quarrying 5,000 years ago, according to a new UCL-led study. Geologists have long known that 42 of Stonehenge’s smaller stones, known as ‘bluestones’, came from the Preseli hills in Pembrokeshire, west Wales. Now a new
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The great white shark is one of the most recognized marine creatures on Earth, generating widespread public fascination and media attention, including spawning one of the most successful movies in Hollywood history. This shark possesses notable characteristics, including its massive size (up to 20 feet and 7,000 pounds) and diving to nearly 4,000 foot depths.
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Climate change is shifting the energy in the atmosphere that fuels summertime weather, which may lead to stronger thunderstorms and more stagnant conditions for midlatitude regions of the Northern Hemisphere, including North America, Europe, and Asia, a new MIT study finds. Scientists report that rising global temperatures, particularly in the Arctic, are redistributing the energy
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From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn’t clear. Using new technology to reveal the 3D organization of DNA in maturing male reproductive cells, scientists revealed a crucial period in development that helps explain how
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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While the polyester leisure suit was a 1970s mistake, polyester and other synthetic fibers like nylon are still around and are a major contributor to the microplastics load in the environment, according to a Penn State materials scientist, who suggests switching to biosynthetic fibers to solve this problem. “These materials, during production, processing and after
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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Abstract Place cells in the mammalian hippocampus signal self-location with sparse spatially stable firing fields. Based on observation of place cell activity it is possible to accurately decode an animal’s location. The precision of this decoding sets a lower bound for the amount of information that the hippocampal population conveys about the location of the
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Syntactic and semantic conventions 1. Taxa are models, concepts are mimics. We typically refrain from using the terms “taxon”, “taxa”, or “clade(s)”. We take taxa to constitute evolutionary, causally sustained entities whose members are manifested in the natural realm. The task for systematics is to successively approximate the identities and limits of these entities. Thus,
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Despite widespread infection, some frog populations are surviving a deadly disease that is the equivalent of humankind’s Ebola virus. The reason — genetic diversity. That’s the finding of a new study published this week in the journal Immunogenetics. Anna Savage, an assistant professor of biology at the University of Central Florida, is the lead author
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Neural stimulation is a developing technology that has beneficial therapeutic effects in neurological disorders, such as Parkinson’s disease. While many advancements have been made, the implanted devices deteriorate over time and cause scarring in neural tissue. In a recently published paper, the University of Pittsburgh’s Takashi D. Y. Kozai detailed a less invasive method of
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The analysis of single-cell RNA sequencing (scRNAseq) data plays an important role in understanding the intrinsic and extrinsic cellular processes in biological and biomedical research. One significant effort in this area is the detection of differentially expressed (DE) genes. scRNAseq data, however, are highly heterogeneous and have a large number of zero counts, which introduces
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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Astronomy & Astrophysics publishes the work of researchers from the University of Vienna, who have found a river of stars, a stellar stream in astronomical parlance, covering most of the southern sky. The stream is relatively nearby and contains at least 4000 stars that have been moving together in space since they formed, about 1
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Like going from a pinhole camera to a Polaroid, a significant mathematical update to the formula for a popular bioinformatics data visualization method will allow researchers to develop snapshots of single-cell gene expression not only several times faster but also at much higher-resolution. Published in Nature Methods, this innovation by Yale mathematicians will reduce the
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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1. Hoglinger, GU, G Respondek and GG Kovacs. New classification of tauopathies. Rev Neurol (Paris) 2018. https://doi.org/10.1016/j.neurol.2018.07.001. 2. Lebouvier T, Pasquier F, Buee L. Update on tauopathies. Curr Opin Neurol. 2017;30:589–98. 3. Morris M, Maeda S, Vossel K, Mucke L. The many faces of tau. Neuron. 2011;70:410–26. 4. Höglinger GU, Melhem NM, Dickson DW, et
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The analytical approach presented above was implemented using R-shiny. The typical analysis is performed by three interaction steps: i) input of gene lists and modifications, ii) graphical visualization of enriched terms and iii) interactive navigation of the results. A step-by-step user manual is available in Additional file 1. In the first step, the application provides a
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The analytical approach presented above was implemented using R-shiny. The typical analysis is performed by three interaction steps: i) input of gene lists and modifications, ii) graphical visualization of enriched terms and iii) interactive navigation of the results. A step-by-step user manual is available in Additional file 1. In the first step, the application provides a
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Identifying and counting individual cells from cell cultures form the basis of numerous biological and biomedical research applications [1, 2]. Determining numbers of cells reflecting the growth, survival, and death of cell populations form the foundations of e.g. basic cancer research and early drug development. Currently, the most commonly used methods for counting cells in
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