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The most distant object humanity has ever visited looks something like a spinning snowman or hourglass that’s lost in space. Researchers who work on NASA’s nuclear-powered New Horizons mission released a movie on Tuesday showing the rotation of the mountain-size rock, which is known formally as (486958) 2014 MU69. (It’s more commonly referred to as “Ultima
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Artificial intelligence provides insights into how deep-learned biochemistry clocks effectively determine biological age of smokers and predict smoking status Insilico Medicine, one of the leaders in artificial intelligence for drug discovery, biomarker development, digital medicine, and aging research, announced the publication of a new collaborative research paper titled “Blood Biochemistry Analysis to Detect Smoking Status
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Brain metastases Brain metastases, Published online: 17 January 2019; doi:10.1038/s41572-018-0055-y An estimated 20% of all patients with cancer will develop brain metastases, with the majority of brain metastases occurring in those with lung and breast cancer and melanoma. This Primer describes the mechanisms by which cancer cells migrate to the brain and the key advances
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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins, Published online: 17 January 2019; doi:10.1038/s41580-018-0089-8 BCL-2 family proteins are the mediators of apoptotic cell death. The balance between pro-apoptotic and pro-survival BCL-2 family members is differently
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Materials GM maize flour i.e. Bt176, GA21, NK603 and TC1507, were supplied by Monsanto Company (St. Louis, MO). Non-transgenic seeds (maize, soybean, rapeseed, wheat) were purchased from a local market in Shanghai, China. The genomic DNAs of four common foodborne pathogenic bacteria i.e. Salmonella, Listeria monocytogenes (L. monocytogenes), Escherichia coli (E. coli) and Staphylococcus aureus
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OK let me see if I got it right. They (Google) used an innovation made by Microsoft (08:57 – 09:29 of the video) in order to make their Neural Network better and then they used already established bioinformatic algorithms. So, this is how their NN is built. Correct? Did I miss anything? Then they run
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Enlarge this image An image, from a scanning electron micrograph, of Heterorhabditis megidis nematode worms (colored blue). These parasitic worms harbor a bacteria that repels mosquitoes. Steve Gschmeissner/Science Source hide caption toggle caption Steve Gschmeissner/Science Source The next great insect repellent might come from a strain of bacteria that lives inside a common parasitic worm.
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GENEVA (Reuters) – A proposed 100-km particle accelerator under Geneva has joined an international quest to develop the successor to the Large Hadron Collider to help unlock humankind’s knowledge of matter. FILE PHOTO: A general view of the Large Hadron Collider (LHC) experiment during a media visit at the Organization for Nuclear Research (CERN) in
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BREAKING AND ENTERING The Extraordinary Story of a Hacker Called Alien By Jeremy N. Smith 292 pp. Houghton Mifflin Harcourt. $28. When the F.B.I. warned the Democratic National Committee that hackers had broken into its system before the 2016 elections, the help desk dismissed it as a potential prank call. And when the Russians used
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When the Fukushima Daiichi Nuclear Power Plant began spewing radioactive particles after it was clobbered by a tsunami in March 2011Kaori Sakumafled. She bundled her infant and toddler into a car and left her husband and family in Koriyama, 44 miles west of the ruptured facility. “The truth is, I ran away,” she says. Confronting
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A 73-year-old woman presented to the dermatology clinic with an 11-month history of an evolving pruritic, erythematous rash on her thighs, buttocks, trunk, and axillae (Panel A). The rash initially consisted of pruritic annular lesions with central duskiness and was treated with prednisone and antihistamines without improvement. The rash evolved into polycyclic erythematous plaques during
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In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases. The study was published recently in Cell Reports. The circadian clock operates within the body and
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Our body’s cells are constantly changing. But which of these changes are healthy developments and which lead to serious diseases? This is what LifeTime, a new transnational and interdisciplinary initiative of leading European researchers, aims to discover. The consortium is jointly coordinated by the Max Delbrück Center in Berlin and the Institut Curie in Paris,
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USP7 activation requires the C-terminal tail in cis The activation of USP7 requires interaction between the CD and the C-terminal peptide (see Fig. 1a for domain definitions and nomenclature). The details of this interaction were described in a recent crystal structure (PDB: 5JTV) of Ubl45 and CD36. This structure clarifies how the activating C-terminal peptide binds,
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Image-based data for a quantitative model selection approach It is currently impossible to obtain time-lapse data of kidney branching morphogenesis in utero. We therefore cultured the dissected wild type (Fig. 2a, Supplementary Movie 1) and mutant kidneys (Supplementary Movies 2, 3) under a fluorescent microscope and imaged the branching process once per hour (for details see “Methods”—Kidney cultures
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Citation: Dube D, Ahalawat N, Khandelia H, Mondal J, Sengupta S (2019) On identifying collective displacements in apo-proteins that reveal eventual binding pathways. PLoS Comput Biol 15(1): e1006665. https://doi.org/10.1371/journal.pcbi.1006665 Editor: Anders Wallqvist, US Army Medical Research and Materiel Command, UNITED STATES Received: July 3, 2018; Accepted: November 23, 2018; Published: January 15, 2019 Copyright: ©
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Abstract Modern optical imaging experiments not only measure single-cell and single-molecule dynamics with high precision, but they can also perturb the cellular environment in myriad controlled and novel settings. Techniques, such as single-molecule fluorescence in-situ hybridization, microfluidics, and optogenetics, have opened the door to a large number of potential experiments, which begs the question of
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design thinkingstoryblocks Over the past few years, design thinking has quickly gained momentum in the business world. Some of the world’s leading brands—the likes of Apple, Google, HBO, Samsung, World Bank, and General Electric—have embraced design thinking as a means of optimizing product innovation. At its core, design thinking is a methodology for creative problem
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Enlarge this image The China National Space Administration’s lunar lander, seen on Jan. 11. China National Space Administration/Xinhua News Agency/AP hide caption toggle caption China National Space Administration/Xinhua News Agency/AP A hint of a cotton plant is growing on the moon, inside China’s lunar lander, scientists in China say. Photos released on Tuesday by Chongqing
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As newborns, we enter the world by inhaling. In leaving, we exhale. (In fact, in many languages the word “exhale” is synonymous with “dying.”) Breathing is so central to life that it is no wonder humankind long ago noted its value not only to survival but to the functioning of the body and mind and
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Australia is sweltering through an intense heatwave this week that’s scorching the country from coast to coast with temperatures as high as 49.3 degrees Celsius (120.7 degrees Fahrenheit). In numerous locations, temperature records have already been broken, with minimum overnight temperatures in three towns of 33°C (91°F) showing even the night offers no escape from
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