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A new era for understanding amyloid structures and disease A new era for understanding amyloid structures and disease, Published online: 20 September 2018; doi:10.1038/s41580-018-0060-8 The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. Recent advances in structural biology techniques have provided insight into
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Mosquito larvae will eat microscopic bits of plastic that can stay in their bodies as they metamorphose into adulthood, researchers have shown for the first time. This means they and similar insects could spread the plastic particles that contaminate aquatic ecosystems—where many bugs spend their infancy—to land predators such as birds or spiders, thus “polluting
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Imagine biting into a juicy beef burger that was produced without killing animals. Meat grown in a laboratory from cultured cells is turning that vision into a reality. Several start-ups are developing lab-grown beef, pork, poultry and seafood—among them Mosa Meat, Memphis Meats, SuperMeat and Finless Foods. And the field is attracting millions in funding.
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Many people with diabetes prick their fingers several times a day to measure blood sugar levels and decide on the insulin doses they need. Implants of pancreatic cells that normally make insulin in the body— so-called islet cells—can render this cumbersome process unnecessary. Likewise, cellular implants could transform treatment of other disorders, including cancer, heart
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To the Editor In the IMpower150 study, Socinski et al. (June 14 issue)1 sought to determine whether vascular endothelial growth factor blockade enhances the efficacy of immunotherapy in patients with advanced nonsquamous non–small-cell lung cancer (NSCLC). To address this question, the study should have compared the experimental group of patients who received atezolizumab plus bevacizumab
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From the Paris Translational Research Center for Organ Transplantation, INSERM, Unité Mixte de Recherche S970 (A.L., C.L.), the Kidney Transplant Department, Necker Hospital, Assistance Publique–Hôpitaux de Paris (AP-HP) (A.L.), and the Kidney Transplant Department, Saint-Louis Hospital, AP-HP (C.L.) — all in Paris. Address reprint requests to Dr. Loupy at the Paris Translational Research Center for
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To the Editor The study by DiNardo and colleagues (June 21 issue)1 showed the activity of ivosidenib (AG-120) in patients who had advanced relapsed or refractory acute myeloid leukemia (AML) with mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) at position R132 (C/G/L/S/H). The overall response rate was 41.6%. The study did not show
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To the Editor: Amyloid A (AA) systemic amyloidosis is a complication of chronic inflammatory diseases that is caused by the deposition of insoluble aggregates of cleaved N-terminal fragments of serum amyloid A (SAA) protein in tissues and organs throughout the body.1 Under physiologic conditions, SAA protein is produced by hepatocytes during the acute inflammatory phase
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A previously healthy 24-year-old man presented to the emergency department with a 1-month history of abdominal distention, abdominal pain, and fever. On physical examination, he was noted to have bulging flanks with a fluid wave. Analyses of ascitic fluid revealed a predominance of lymphocytes, a high protein level that was similar to that in serum,
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To the Editor In their report on the Pediatric Emergency Care Applied Research Network trial of fluid infusion rates in patients with diabetic ketoacidosis (PECARN DKA FLUID), Kuppermann et al. (June 14 issue)1 do not provide data on whether there was a correlation between a decrease in the effective plasma osmolality and deterioration in the
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Audio Interview Interview with Dr. Jerry Avorn on the FDA Amendments Act of 2007 and the effort to make data on drug safety more transparent and available. (10:13) Download Prescription-drug policy in the United States has developed through a process of punctuated evolution, often driven by crises. Progressive-era concern about “patent medicines” that contained primarily
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Early on the night of May 5, a team of scientists snuck out onto the white beaches of south Florida to attach a transmitter in the shell of a nesting leatherback turtle (Dermochelys coriacea). They nicknamed her Isla, and for months, members of the non-profit organisation Florida Leatherbacks, Inc. have been following this turtle as
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Computational tools to unmask transposable elements Computational tools to unmask transposable elements, Published online: 19 September 2018; doi:10.1038/s41576-018-0050-x The repetitive nature of transposable elements (TEs) creates bioinformatic challenges that frequently result in them being disregarded (‘masked’) in analyses. As physiological and pathological roles for TEs become increasingly appreciated, this Review discusses bioinformatics tools dedicated to
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Citation: Babichev A, Morozov D, Dabaghian Y (2018) Robust spatial memory maps encoded by networks with transient connections. PLoS Comput Biol 14(9): e1006433. https://doi.org/10.1371/journal.pcbi.1006433 Editor: Peter Hellyer, King’s College London, UNITED KINGDOM Received: January 10, 2018; Accepted: August 15, 2018; Published: September 18, 2018 Copyright: © 2018 Babichev et al. This is an open access
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Abstract Dynamics of biomolecular assemblies offer invaluable insights into their functional mechanisms. For extremely large biomolecular systems, such as HIV-1 capsid that has nearly 5 millions atoms, obtaining its normal mode dynamics using even coarse-grained models can be a challenging task. In this work, we have successfully carried out a normal mode analysis of an
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For hundreds of years, geologists have thought the modern-day British mainland was formed by the collision of two ancient land masses, Avalonia and Laurentia. Now, new research suggests a third continent was involved – Armorica, which today makes up the northwestern region of France. That’s according to some geological detective work that considers, among other
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In coming weeks, long after Hurricane Florence’s winds and rains have faded, its aftermath will still pose life-threatening hazards: snakes, submerged sharp objects, bacterial infections and disease-carrying mosquitoes. People are trapped by floodwaters and facing dwindling supplies of medicines, food and drinking water. Carbon monoxide poisoning is a danger as people crank up portable generators,
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It was called the Storegga Slide: a massive underwater landslide off the coast of Norway, which generated a towering 20-metre-high (66 ft) tsunami sweeping across the UK’s Shetland Islands. Luckily, that ancient wave of destruction – which also struck mainland Scotland, Norway, and Greenland – happened over 8,000 years ago, leading scientists to think such
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Progress and potential in organoid research Progress and potential in organoid research, Published online: 18 September 2018; doi:10.1038/s41576-018-0051-9 Organoids are 3D structures derived from stem cells that recapitulate some key characteristics of real organs. The authors review recent progress in organoid derivation and applications and outline how advances in other disciplines might lead to more
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Stem cell fate in cancer growth, progression and therapy resistance Stem cell fate in cancer growth, progression and therapy resistance, Published online: 18 September 2018; doi:10.1038/s41568-018-0056-x This Review discusses how cells with stem cell characteristics often serve as the tumour cell of origin, as they are preferentially primed for transformation. Furthermore, the activation of stem
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Cardioimmunology: the immune system in cardiac homeostasis and disease Cardioimmunology: the immune system in cardiac homeostasis and disease, Published online: 18 September 2018; doi:10.1038/s41577-018-0065-8 Recent studies have characterized complex interactions between resident and infiltrating immune cells in the heart and cardiac cells, including cardiomyocytes, fibroblasts and endothelial cells. This Review explores the role of immune
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The (chain) terminators The (chain) terminators, Published online: 18 September 2018; doi:10.1038/s41580-018-0063-5 The introduction of DNA-chain terminators for sequencing by Fred Sanger enabled the early genome sequencing projects.
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Regulation of microRNA biogenesis and its crosstalk with other cellular pathways Regulation of microRNA biogenesis and its crosstalk with other cellular pathways, Published online: 18 September 2018; doi:10.1038/s41580-018-0059-1 The cleavage of microRNA (miRNA) precursors by Drosha and Dicer and their loading with Argonaute proteins into RNA-induced silencing complexes are key steps in miRNA biogenesis. Recent
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With the advent of the genomic era, doctors can utilize genetic data to analyze the mechanisms of diseases and customize medical treatment. Diseases are usually associated with genetic variants, mainly single nucleotide polymorphisms (SNPs) or simple sequence length polymorphic markers (SSLPs), which are already a valuable source for mapping complex diseases and complex genetic traits
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The first vaginal ring contraceptive that women can use for a full year has received FDA approval. In comparison, a contraceptive ring currently marketed in the United States has to be replaced monthly. Hallie Easley/Population Council Made of soft, nonbiodegradable silicone, the contraceptive ring prevents pregnancy by releasing a novel progestin, segesterone acetate, and the
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