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Hurricane Florence made landfall as a Category 1 storm near Wrightsville Beach, North Carolina, on Friday, September 14, 2018, with 90-mph winds. At the same time, 3 other named storms—Helene, Isaac, and Joyce—roamed the Atlantic; Tropical Storm Olivia had just passed over Hawaii; and “Super Typhoon” Mangkhut, the strongest tropical cyclone of 2018, was hours
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In ageing research, the lifespan of an organism is an indicator for determining factors that play a role in this process. These ageing factors (AFs) can be genes, chemical compounds or other factors like dietary restriction. Usually, they are examined under different experimental conditions in model organisms like the worm (Caenorhabditis elegans), yeast (Saccharomyces cerevisiae),
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The rate of severe maternal morbidity in US hospitals increased 45% between 2006 and 2015, according to a recent report from the Agency for Healthcare Research and Quality (AHRQ). During that 10-year period, the severe maternal morbidity rate increased from 101 per 10 000 delivery hospitalizations to 147 per 10 000, the authors found, noting that previous
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Since the passage of the Affordable Care Act, there has been an unprecedented pace of testing new payment models to increase health care value. These models have been directed across the continuum of health care professionals and organizations, including physicians, hospitals, and post-acute care facilities. Collectively, these models aim to combine financial incentives for efficient
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The US Preventive Services Task Force (USPSTF) has recently published recommendations on screening for intimate partner violence, elder abuse, and abuse of vulnerable adults. The Problem of Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults Intimate partner violence, also called domestic or dating violence, can be physical, sexual, or psychological (for example, stalking).
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Supplementing diets with n-3 (omega-3) fatty acids did not prevent serious vascular events in patients with diabetes mellitus, found a trial in the New England Journal of Medicine. The 15 480 trial participants with diabetes but no atherosclerotic cardiovascular disease were randomly assigned to receive 1-g capsules of either n −3 fatty acids or an olive-oil
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To the Editor Dr Costa and colleagues for the UK WOLLF Collaborators found no improvement in disability at 12 months in patients with severe open fractures of the lower limb who received negative pressure wound therapy (NPWT) vs standard wound management.1 I would like to address some issues in the study. First, differences between NPWT
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Abstract The development of novel therapeutics is urgently required for diseases where existing treatments are failing due to the emergence of resistance. This is particularly pertinent for parasitic infections of the tropics and sub-tropics, referred to collectively as neglected tropical diseases, where the commercial incentives to develop new drugs are weak. One such disease is
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Abstract We have developed an easy-to-use and memory-efficient method called PhenotypeSeeker that (a) identifies phenotype-specific k-mers, (b) generates a k-mer-based statistical model for predicting a given phenotype and (c) predicts the phenotype from the sequencing data of a given bacterial isolate. The method was validated on 167 Klebsiella pneumoniae isolates (virulence), 200 Pseudomonas aeruginosa isolates
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Citation: Brinkman BAW, Rieke F, Shea-Brown E, Buice MA (2018) Predicting how and when hidden neurons skew measured synaptic interactions. PLoS Comput Biol 14(10): e1006490. https://doi.org/10.1371/journal.pcbi.1006490 Editor: Jeff Beck, Duke University, UNITED STATES Received: December 7, 2017; Accepted: September 5, 2018; Published: October 22, 2018 Copyright: © 2018 Brinkman et al. This is an open
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The cities of the future will have to be bigger, better and smarter than anything built before. In some ways they are already under construction: think of London’s Shard tower, or Dubai’s Burj Khalifa – the world’s tallest building – or even the awe-inspiring complexity of hidden structures such as Crossrail’s 42-kilometre web of new
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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The possibility of life on Mars may not be consigned to the distant past. New research suggests our neighboring world could hide enough oxygen in briny liquid water near its surface to support microbial life, opening up a wealth of potentially habitable regions across the entire planet. Although the findings do not directly measure the
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Pictured here are surgeons performing a gastric bypass. (Photo by Shawn Patrick Ouellette/Portland Press Herald via Getty Images) Think of bariatric surgery as completing the first quarter in a football game, the first chapter in a book, or the first scene in a movie. The story doesn’t end once the surgery is done, as s study just
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Posted by: RNA-Seq Blog in Statisitcal Analysis 3 hours ago 89 Views High-throughput expression profiling experiments with ordered conditions (e.g. time-course or spatial-course) are becoming more common for studying detailed differentiation processes or spatial patterns. Identifying dynamic changes at both the individual gene and whole transcriptome level can provide important insights about genes, pathways, and
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Video Published OnOct. 22, 2018 California’s Underwater Forests Are Being Eaten by the ‘Cockroaches of the Ocean’ By Kendra Pierre-Louis Oct. 22, 2018 ALBION, Calif. — Early on a gray summer Saturday, an unusual assemblage — commercial fishermen, recreational boaters, neoprene-clad divers — gathered for a mission at Albion Cove, a three-hour drive north of
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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The ability to translate the genetic code into proteins is an essential step in all living organisms. A cornerstone of this molecular process is the ability of transfer RNA (tRNA) molecules to couple recognition of the genetic code with the cognate amino acid, which are the building blocks of proteins. Chemical modification of individual tRNAs
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ZURICH (Reuters) – Roche’s Tecentriq plus chemotherapy boosted lung cancer patients’ survival by nearly five months, study data released on Monday showed, underscoring benefits of the Swiss group’s immunotherapy but still leaving it trailing a rival’s drug. FILE PHOTO: The logo of Swiss drugmaker Roche is seen at its headquarters in Basel, Switzerland February 1,
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A deep-sea swimming sea cucumber, Enypniastes eximia, also known as a headless chicken monster, has been filmed for the first time in Southern Ocean waters off East Antarctica using underwater camera technology developed by Australian researchers. The creature, which has only been filmed before in the Gulf of Mexico, was discovered in 3 kilometres of
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Trial Design and Population This randomized, double-blind, placebo-controlled, phase 3 trial was conducted at 16 medical centers in the United States. Before we randomly assigned the patients to receive a trial drug or placebo, we obtained written informed consent from the patients or their authorized representatives. The institutional review board at each participating center approved
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Perhaps the most vexing problem in a patient in an intensive care unit (ICU) is an unexpected change in mental status. Historically, “acute encephalopathy” was the term used to encompass such alterations, but “delirium” is now used to describe this state. The Oxford English Dictionary defines delirium as “an acutely disturbed state of mind characterized
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The design presented in this paper should be regarded as one acceptable approach with respect to the the aforementioned requirements. However, numerous other frameworks, architectures, and configurations could potentially prove adequate. In this section, our reasons for favoring this system will be explained more thoroughly. The research conducted during the course of this project resulted
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Visualizations include display of nucleotide and amino acid substitutions occurring along a user-defined sequence interval (summary plots via baseml) and along the phylogenetic tree (via codeml). Transition (Ts: A↔G, C↔T) and transversion (Tv: A↔C, A↔T, G↔C, G↔T) substitutions are analyzed by codon position (Fig. 1) and then frequency plots summarize the overall accumulation of Ts and
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Human Immunodeficiency Virus (HIV) is a major pandemic disease [1]. More than 36 million people have been infected and about half of these people receive anti-retroviral therapy [2]. However, retroviruses like HIV mutate rapidly since the conversion from the RNA genome to DNA is error-prone [3]. They readily form quasi-species and distinct viral strains. Therefore,
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Determining ‘who infected whom’ during an outbreak can yield precious insights into transmission dynamics of an infectious disease and subsequently inform infection control policies. Transmission tree reconstruction has been used to specify the contribution of individual cases and locations to overall transmission [1], characterise heterogeneous infectiousness within outbreaks [2, 3], evaluate the impact of control
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emClarity: software for high-resolution cryo-electron tomography and subtomogram averaging emClarity: software for high-resolution cryo-electron tomography and subtomogram averaging, Published online: 22 October 2018; doi:10.1038/s41592-018-0167-z A software tool, emClarity, implements several improvements in cryo-electron tomography image-processing algorithms to achieve sub-nanometer resolution for diverse macromolecular structures.
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Going to the negative: genomics for optimized medical prescription Going to the negative: genomics for optimized medical prescription, Published online: 22 October 2018; doi:10.1038/s41576-018-0061-7 In personalized medicine, a major aim is to provide the right treatment to the right patient. In this Comment article, Gibson discusses how a more overt and genomics-informed focus on those
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MUNICH (Reuters) – German drugmaker Merck KGaA might agree partnership deals to jointly develop two of its most promising experimental medicines with a rival as early as this year, but more likely in 2019, its drug research and development chief said on Sunday. A logo of drugs and chemicals group Merck KGaA is pictured in
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Since the dawn of man, we’ve been searching for ways to escape our mortality. The long-sought “fountain of youth” may not lie in divine water or a miracle pill, but rather, in something as simple as the foods we eat and the way we live. Portrait Person Old Man Manhttps://www.maxpixel.net/Portrait-Person-Old-Man-Man-Head-Look-Arabic-1615262 In 2016, for the first time in
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MUNICH (Reuters) – Roche’s entrectinib cancer pill was shown to shrink tumors in 57 percent of patients within a group that can only be identified via genetic profiling, as the Swiss drugmaker challenges an alliance of Bayer and Loxo Oncology in a new targeted treatment area. FILE PHOTO: The logo of Swiss pharmaceutical company Roche
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