Humans

On a personal note, one of the joys of my position as Editor in Chief of JAMA and the JAMA Network is to meet and talk with individuals whom I have admired my entire academic career. Such was the case in meeting and discussing this article with Lisa and Steven. They clearly had boundless energy
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This article has no abstract; the first 100 words appear below. To the Editor: The findings reported by Mazer et al. (Sept. 27 issue)1 in the Transfusion Requirements in Cardiac Surgery (TRICS) trial lend further support to the purported harms of blood transfusion in patients undergoing cardiac surgery. These include tissue ischemia,2 increased red-cell aggregation,3
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This article has no abstract; the first 100 words appear below. To the Editor: In the review article by Fuster and Samet (Sept. 27 issue)1 regarding alcohol use in patients with chronic liver disease, the authors rightly consider short-acting benzodiazepines (oxazepam and lorazepam) to be the cornerstone of treatment for the alcohol withdrawal syndrome. In
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This article has no abstract; the first 100 words appear below. The article by Moore et al.1 in this issue of the Journal is the culmination of a long march for olaparib in the treatment of BRCA-mutated high-grade serous ovarian cancer — one that began with its discovery by means of synthetic lethality screening, followed
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An 84-year-old man presented to the primary care clinic with fever, malaise, and discoloration and pain in the fingers and toes that had progressed over a 2-week period. He had no history of smoking. The patient had a body temperature of 37.8°C. A physical examination was notable for blue-black discoloration of the distal second through
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This article has no abstract; the first 100 words appear below. To the Editor: Hu et al. (Aug. 16 issue)1 conclude in their study that the survival benefit after smoking cessation was not affected by weight gain. In contrast, as presented the data support a different interpretation — patients with moderate weight gain (5.1 to
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Diana Bianchi, MD, has referred to the placenta as the Rodney Dangerfield of organs because it’s typically given little thought during pregnancy and discarded after delivery. The late Dangerfield, a comedian and actor, was best-known for his catchphrase, “I don’t get no respect.” Linda Huynh/Eunice Kennedy Shriver National Institute of Child Health and Human Development
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An alarming rise in firearm homicides between 2012 and 2016 in major metropolitan areas has erased progress toward reducing such deaths in the past decade, according to a CDC report that analyzed data from the National Vital Statistics System and the US Census Bureau. Left, iStock.com/wwing; In the agency’s last report, the rate of firearm
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Knowing only life expectancy, child mortality, and the rate of death related to opioids, is it possible to guess whether a US county voted Democratic or Republican in the 2016 Presidential election? iStock.com/DNY59 And the answer is: No, it’s not possible. As students and faculty at the Johns Hopkins Bloomberg School of Public Health discovered
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Importance  In-flight medical emergencies (IMEs) are common and occur in a complex environment with limited medical resources. Health care personnel are often asked to assist affected passengers and the flight team, and many have limited experience in this environment. Observations  In-flight medical emergencies are estimated to occur in approximately 1 per 604 flights, or 24
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The Departments of Health and Human Services (HHS), Treasury, and Labor recently announced 2 final rules that exempt employers from providing health insurance coverage for contraceptives if they have religious or moral objections to it. Final rules announced for contraceptive coverage exemptions based on moral or religious objections. BSIP/sciencesource.com The Affordable Care Act (ACA) exempted
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By the time my father died, it wasn’t a surprise. It was scary and sad, but it was also a terrible sort of relief. It was an unglamorous death in the Canal Street apartment he had chosen for its expansive, unfinished rooftop on which he tended his clivia and miniature lemon trees. Empty bottles of
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Physicians are familiar with the yearly routine of being screened for tuberculosis, reviewing their vaccine status, and getting the influenza vaccination. Should physicians also be screened for mental health conditions such as depression or burnout? The prevalence of and challenges associated with depression, burnout, and suicide have been increasingly recognized. Physicians die by suicide at
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May you take counsel Before mask and gown, May you measure twice But only sever once, May your fingers feel What lies deep unseen, May bleeding cease with Practiced gentleness, May your sutures hold The tissue true and fast May panic never strike When failure looms, May you think clearly When you lose your way
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A 46-year-old man presented to the emergency department with worsening chronic left knee pain. Fourteen years before presentation, he had sustained a gunshot wound to the left knee. Radiographs obtained at the time of that injury showed a metallic bullet embedded in the posterior weight-bearing surface of the lateral femoral condyle and metallic debris within
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An 18-year-old man presented to the emergency department with chest pain. He had a history of Kawasaki’s disease, which had been diagnosed when he was 11 years of age. Despite treatment with intravenous immune globulin, coronary-artery aneurysms were detected on imaging (Panel A shows a coronary angiogram obtained 3 years before the current presentation). At
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This article has no abstract; the first 100 words appear below. To the Editor: In his article, Insogna (Sept. 13 issue)1 notes that “surgical treatment of hyperparathyroidism should incorporate intraoperative PTH [parathyroid hormone] measurements where available.” We disagree with this recommendation. Intraoperative PTH measurements may be used during focused surgery targeting a presumed single adenoma
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Supported by grants from the National Cancer Institute, National Institutes of Health (U10CA180821, U10CA180882, and U24CA196171 to the Alliance for Clinical Trials in Oncology; U10CA180833, U10CA180838, U10CA180857, U10CA180858, UG1CA189850, UG1CA189957, U10CA180820 [to the Eastern Cooperative Oncology Group–American College of Radiology Imaging Network], U10CA180868 [to NRG], U10CA180888, and U10CA180826 [to the Southwest Oncology Group]), Bayer Pharmaceuticals,
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From the University of Michigan Injury Prevention Center (R.M.C., M.A.W., P.M.C.), the Firearm Safety among Children and Teens Consortium (R.M.C., M.A.W., P.M.C.), the Department of Emergency Medicine (R.M.C., P.M.C.), and the Addiction Center, Department of Psychiatry (M.A.W.), University of Michigan School of Medicine, and the Youth Violence Prevention Center (R.M.C., P.M.C.) and Department of Health
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This article has no abstract; the first 100 words appear below. Children in America are dying or being killed at rates that are shameful. The sad fact is that a child or adolescent in the United States is 57% more likely to die by the age of 19 years than those in other wealthy nations.1
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High costs, variable quality, and substantial waste in the US health care system have led governments, payers, and health care organizations to pursue physician accountability and quality improvement efforts aimed at producing higher-value care.1 These efforts, such as Medicare’s Value-Based Payment Modifier and many commercial performance-based payment programs, often use pay-for-performance (P4P) and other financial
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Leaders from around the world have endorsed the Declaration of Astana, a resolution that vows to strengthen primary health care as a cornerstone to achieving worldwide universal health care. The declaration, signed in Astana, the current capital of Kazakhstan, will also bolster efforts toward attaining a United Nations Sustainable Development Goal to “ensure healthy lives
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After a 7-year absence, the asthma drug Primatene Mist will return to over-the-counter (OTC) sales for patients with mild, intermittent asthma. The drug was taken off the market in 2011 because it contained chlorofluorocarbon propellants, which are known to deplete the ozone layer. The new version contains hydrofluoroalkane propellants, which are allowed under international and
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A common African rodent is to blame for an abnormal increase in Lassa fever cases during a 2018 outbreak in Nigeria, according to a recent analysis. The data quelled concerns that the surge in cases resulted from a new, more virulent strain of the virus that could spread quickly among humans. The increase in Lassa
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The Gleason score is the best independent predictor of prostate cancer outcomes.1 The principle distinction between Gleason 6 disease vs Gleason 7 to 10 disease is that Gleason 6 disease does not necessarily need definitive treatment.2 Nevertheless, the implications of Gleason score are less clear in black men because of disparate prostate cancer outcomes, particularly
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Original Investigation Opioids for Chronic Noncancer Pain Jason W. Busse, DC, PhD; Li Wang, PhD; Mostafa Kamaleldin, MB BCh; Samantha Craigie, MSc; John J. Riva, DC, MSc; Luis Montoya, DDS, MSc; Sohail M. Mulla, PhD; Luciane C. Lopes, ScD, MSc; Nicole Vogel, PhD; Eric Chen, BHSc; Karin Kirmayr, MD; Kyle De Oliveira, MD; Lori Olivieri, MD; Alka Kaushal, MBBS, DA; Luis E. Chaparro, MD; Inna Oyberman, MD; Arnav Agarwal, MD; Rachel Couban, MA, MISt; Ludwig Tsoi, MBChB; Tommy Lam, MBBS; Per Olav Vandvik, MD, PhD; Sandy Hsu, BA; Malgorzata M. Bala, MD; Stefan Schandelmaier, MD; Anne Scheidecker, MD; Shanil Ebrahim, PhD; Vahid Ashoorion, MD, PhD; Yasir Rehman, MD, MSc; Patrick J. Hong, BMSc;
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Importance  Among adults with chronic illness, 30% to 50% of medications are not taken as prescribed. In the United States, it is estimated that medication nonadherence is associated with 125 000 deaths, 10% of hospitalizations, and $100 billion in health care services annually. Observations  PubMed was searched from January 1, 2000, to September 6, 2018, for
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The ubiquitous social media landscape has created an information ecosystem populated by a cacophony of opinion, true and false information, and an unprecedented quantity of data on many topics. Policy makers and the social media industry grapple with the challenge of curbing fake news, disinformation, and hate speech; and the field of medicine is similarly
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Two fire technicians have died after a generator incident occurred at one of the largest stations in Antarctica. According to the National Science Foundation (NSF), on 12 December, the two technicians were performing routine maintenance on a generator building’s fire suppression system. The generator powers a radio transmitter nearby the station. Unfortunately, the maintenance did not
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This article has no abstract; the first 100 words appear below. The mitral valve is a complex structure encompassing the valve leaflets, annulus, chordae tendineae, and papillary muscles.1 Primary mitral regurgitation is caused by a primary leaflet abnormality, whereas secondary mitral regurgitation occurs when structurally normal valve leaflets are unable to coapt completely owing to
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