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Trends driving clinical trials into large clinical care settings Trends driving clinical trials into large clinical care settings, Published online: 20 July 2018; doi:10.1038/nrd.2018.111 This analysis highlights data indicating the limitations of traditional clinical trial processes, and discusses how moving clinical trials into large clinical care settings could help meet the growing demands for large
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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1. Wang, Z. et al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat. Genet. 40, 897–903 (2008). This study investigates the extent to which gene-specific combinatorial patterns of histone modifications exist in promoter and enhancer regions of human CD4 + T cells and identifies a common modification module consisting of 17
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1. Gray, M. W. & Archibald, J. M. in Genomics of Chloroplasts and Mitochondria, Advances in Photosynthesis and Respiration (eds Bock, R. & Knoop, V.) 1–30 (Springer, 2012). 2. Burton, R. S. & Barreto, F. S. A disproportionate role for mtDNA in Dobzhansky-Muller incompatibilities? Mol. Ecol. 21, 4942–4957 (2012). This review argues for a special
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Instructive power of senescence Instructive power of senescence, Published online: 17 July 2018; doi:10.1038/s41580-018-0042-x Senescent cells secrete a multitude of factors that modulate their local environment — a phenomenon known as senescence-associated secretory phenotype (SASP). David Bernard highlights that the SASP secretome can be flexibly regulated, resulting in different types of SASP, which contributes to
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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Bacterial adhesion at the single-cell level Bacterial adhesion at the single-cell level, Published online: 15 July 2018; doi:10.1038/s41579-018-0057-5 In this Review, Brun and colleagues summarize our understanding of the mechanisms governing bacterial adhesion at the single-cell level, including the physical forces experienced by a cell before reaching the surface, the first contact with a surface
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Structural insights into the signalling mechanisms of two-component systems Structural insights into the signalling mechanisms of two-component systems, Published online: 15 July 2018; doi:10.1038/s41579-018-0055-7 Canonical two-component systems catalyse autophosphorylation of the histidine kinase, transfer of the phosphoryl group to the regulator and dephosphorylation of the phosphoregulator. In this Progress article, Jacob-Dubuisson and colleagues highlight recent
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Quorum sensing in the immune system Quorum sensing in the immune system, Published online: 13 July 2018; doi:10.1038/s41577-018-0040-4 Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence.
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment Extracellular ATP and P2 purinergic signalling in the tumour microenvironment, Published online: 13 July 2018; doi:10.1038/s41568-018-0037-0 In this Review, Di Virgilio et al. describe how extracellular ATP and P2 purinergic signalling can shape the tumour microenvironment to both promote and restrain tumour progression and outline
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Autophagy as a promoter of longevity: insights from model organisms Autophagy as a promoter of longevity: insights from model organisms, Published online: 13 July 2018; doi:10.1038/s41580-018-0033-y Recent studies in model organisms uncovered prominent links between autophagy and ageing, suggesting that by removing superfluous or damaged cellular content through lysosomal degradation, autophagy supports tissue and organismal
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Every step of the way: integrins in cancer progression and metastasis Every step of the way: integrins in cancer progression and metastasis, Published online: 12 July 2018; doi:10.1038/s41568-018-0038-z In this Review, Hamidi and Ivaska discuss the contribution of integrins to the different steps of cancer progression, highlighting some of the recently identified unconventional roles of
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Multidrug efflux pumps: structure, function and regulation Multidrug efflux pumps: structure, function and regulation, Published online: 12 July 2018; doi:10.1038/s41579-018-0048-6 One factor contributing to the emergence of antimicrobial resistance is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. This Review describes recent insights into the structure, function and
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1. Golgi, C. Sulla Fina Anatomia Degliorgani Centrali del Sistema Nervosa. Revista Sperimentale di Freniatria Reprinted in Golgi, C. Opera Omnia (1903) (Milano, 1885). 2. Cajal, S. R. Estructura del cerebelo. Gac. Med. Catalana 11, 449–457 (1888). 3. Jones, E. G. Colgi, Cajal and the neuron doctrine. J. Hist. Neurosci. 8, 170–178 (1999). This article
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The genetics of loneliness The genetics of loneliness, Published online: 11 July 2018; doi:10.1038/s41576-018-0036-8 One in four UK adults over the age of 65 suffers from loneliness. An analysis of UK Biobank data has identified 15 genomic loci associated with loneliness and reports a possible causal link between obesity and loneliness and depression.
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Gene dimmer switch Gene dimmer switch, Published online: 11 July 2018; doi:10.1038/s41580-018-0038-6 The chromatin remodelling complex NuRD fine-tunes gene expression by modulating nucleosome density at gene regulatory elements.
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Diagnosis and management of Cornelia de Lange syndrome: first international consensus statement Diagnosis and management of Cornelia de Lange syndrome: first international consensus statement, Published online: 11 July 2018; doi:10.1038/s41576-018-0031-0 Cornelia de Lange syndrome is a genetic disorder affecting multiple organ systems that exhibits great phenotypic heterogeneity. This Consensus Statement summarizes recommendations for the diagnosis
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Converging inputs Converging inputs, Published online: 10 July 2018; doi:10.1038/s41583-018-0040-1 A study in flies shows that projections from some groups of glomerular neurons converge on certain types of lateral horn neurons to process combinations of odours that are salient for certain behaviours.
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STAT3 on the brain STAT3 on the brain, Published online: 09 July 2018; doi:10.1038/s41568-018-0042-3 Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
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RFX7 keeps killers quiescent RFX7 keeps killers quiescent, Published online: 06 July 2018; doi:10.1038/s41577-018-0039-x The metabolism and maintenance of natural killer (NK) cells is regulated by a previously uncharacterized transcription factor called regulatory factor X7 (RFX7).
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Ewing sarcoma Ewing sarcoma, Published online: 05 July 2018; doi:10.1038/s41572-018-0003-x Ewing sarcoma is a malignant bone or soft-tissue tumour that mainly affects children, adolescents and young adults. This Primer describes the key characteristic molecular features of and the remaining unanswered research questions in Ewing sarcoma.
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Modelling microglial function with induced pluripotent stem cells: an update Modelling microglial function with induced pluripotent stem cells: an update, Published online: 05 July 2018; doi:10.1038/s41583-018-0030-3 In recent years, several studies have reported the production of microglia-like cells from induced pluripotent stem cells. Pocock and Piers describe the methods used to produce and analyse these
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Population genomics of bacterial host adaptation Population genomics of bacterial host adaptation, Published online: 04 July 2018; doi:10.1038/s41576-018-0032-z High-throughput sequencing technologies have enabled comparative analysis of large numbers of diverse bacterial genomes. Such studies are providing insights into the genomic changes that accompany changes in host specificity, with possible implications for controlling transmission of pathogenic
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