The role of engram cells in the systems consolidation of memory The role of engram cells in the systems consolidation of memory, Published online: 03 July 2018; doi:10.1038/s41583-018-0031-2 Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss
Tissue-specific functions of invariant natural killer T cells Tissue-specific functions of invariant natural killer T cells, Published online: 02 July 2018; doi:10.1038/s41577-018-0034-2 Here, the authors examine the functions of different subsets of invariant natural killer T (iNKT) cells. They explain how iNKT cells contribute to tissue homeostasis and protection against infection, with a focus on
Breakdancing on actin Breakdancing on actin, Published online: 02 July 2018; doi:10.1038/s41580-018-0036-8 Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.
From rock ‘n’ roll to heavy metal From rock ‘n’ roll to heavy metal, Published online: 28 June 2018; doi:10.1038/s41568-018-0041-4 Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.
Influenza Influenza, Published online: 28 June 2018; doi:10.1038/s41572-018-0002-y Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. This Primer discusses the biological features of influenza viruses, their effects on human and animal health and the mitigation strategies to reduce the burden of this disease.
Sleep it off Sleep it off, Published online: 26 June 2018; doi:10.1038/s41583-018-0037-9 A set of 80 (mostly synaptic) proteins show hyperphosphorylation in sleep-deprived mice and genetically ‘sleepy’ mice, suggesting that increased phosphorylation of such proteins may be associated with sleep need.
Success stories Success stories, Published online: 22 June 2018; doi:10.1038/s41568-018-0039-y Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.
Prospecting for pluripotency Prospecting for pluripotency, Published online: 22 June 2018; doi:10.1038/s41576-018-0030-1 Unlike most organisms, planaria maintain pluripotent stem cells (PSCs) beyond embryogenesis. A new study reports the prospective identification and isolation of a neoblast subpopulation containing adult PSCs, characterization of which should help uncover the mechanisms underlying pluripotency and tissue regeneration.
Tumours trigger systemic disruption Tumours trigger systemic disruption, Published online: 21 June 2018; doi:10.1038/s41568-018-0040-5 Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).