Reviews

The role of engram cells in the systems consolidation of memory The role of engram cells in the systems consolidation of memory, Published online: 03 July 2018; doi:10.1038/s41583-018-0031-2 Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss
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Tissue-specific functions of invariant natural killer T cells Tissue-specific functions of invariant natural killer T cells, Published online: 02 July 2018; doi:10.1038/s41577-018-0034-2 Here, the authors examine the functions of different subsets of invariant natural killer T (iNKT) cells. They explain how iNKT cells contribute to tissue homeostasis and protection against infection, with a focus on
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Breakdancing on actin Breakdancing on actin, Published online: 02 July 2018; doi:10.1038/s41580-018-0036-8 Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.
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From rock ‘n’ roll to heavy metal From rock ‘n’ roll to heavy metal, Published online: 28 June 2018; doi:10.1038/s41568-018-0041-4 Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.
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Influenza Influenza, Published online: 28 June 2018; doi:10.1038/s41572-018-0002-y Influenza is an infectious respiratory disease that, in humans, is caused by influenza A and influenza B viruses. This Primer discusses the biological features of influenza viruses, their effects on human and animal health and the mitigation strategies to reduce the burden of this disease.
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Sleep it off Sleep it off, Published online: 26 June 2018; doi:10.1038/s41583-018-0037-9 A set of 80 (mostly synaptic) proteins show hyperphosphorylation in sleep-deprived mice and genetically ‘sleepy’ mice, suggesting that increased phosphorylation of such proteins may be associated with sleep need.
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Success stories Success stories, Published online: 22 June 2018; doi:10.1038/s41568-018-0039-y Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.
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Prospecting for pluripotency Prospecting for pluripotency, Published online: 22 June 2018; doi:10.1038/s41576-018-0030-1 Unlike most organisms, planaria maintain pluripotent stem cells (PSCs) beyond embryogenesis. A new study reports the prospective identification and isolation of a neoblast subpopulation containing adult PSCs, characterization of which should help uncover the mechanisms underlying pluripotency and tissue regeneration.
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Tumours trigger systemic disruption Tumours trigger systemic disruption, Published online: 21 June 2018; doi:10.1038/s41568-018-0040-5 Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).
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