Most of us learn how to ride a bike during childhood. But as we grow older, many of us stop riding and put those once-beloved bikes in storage. Years later, when we discover these relics and hop on, it’s as if we never stopped biking. This is surprising because our memories let us down in
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The analysis of transcriptome data from non-model organisms contributes to our understanding of diverse aspects of evolutionary biology, including developmental processes, speciation, adaptation, and extinction. Underlying this diversity is one shared feature, the generation of enormous amounts of sequence data. Data availability requirements in most journals oblige researchers to make their raw transcriptome data publicly
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At the London Restaurant Festival, Sebastian Valouch is looking very slightly on edge. “I know the technology works,” he says. “But demonstrations always make you feel a little nervous.” He is talking about the latest innovation from his employer, the BASF subsidiary company trinamiX GmbH. It’s a prototype handheld spectrometer, a point-and-click device that can
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Neural nets supplant marker genes in analyzing single cell RNA sequencing | RNA-Seq Blog Don’t Miss Posted by: RNA-Seq Blog in Commentary 13 hours ago 302 Views CMU’s scQuery Web Server Uses New Method To Determine Cell Types, Identify Key Genes Computer scientists at Carnegie Mellon University say neural networks and supervised machine learning techniques
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Antibiotic resistance genes have now been found in the penguins near the O’Higgins research baseStone Monki/CC-BY-3.0 By Chris Baraniuk Humans have spread antibiotic resistance so far and wide that diverse clusters of microbes with resistance genes are now turning up in the gut microbiome of penguins in Antarctica. Antibiotic-resistance can occur naturally, and microbes with
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For a brief moment earlier this year, a small spot in China blazed with such heat, the Sun would have been staring down at Earth feeling mightily jealous. Scientists announced this week that the Experimental Advanced Superconducting Tokamak (EAST) reactor in Hefei has finally achieved a temperature exceeding 100 million degrees Celsius, setting a new
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Scientists behind a major study that claimed the Earth’s oceans are warming faster than previously thought now say their work contained inadvertent errors that made their conclusions seem more certain than they actually are. Two weeks after the high-profile study was published in the journal Nature, its authors have submitted corrections to the publication. The
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China has halted a directive that partially legalized the domestic trade in farmed rhinoceros and tiger parts, two weeks after the move drew a torrent of criticism from conservation groups. A senior official in China’s cabinet said in a state media interview published Monday that implementation of an October directive reviving the market for the
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Amaryllis Nucleics, a Bay Area biotech company using the most advanced chemistry for RNA sequencing sample prep to provide rapid and accurate RNA sequencing, today launched a new version of their dual-mode (FT+3′-DGE) RNA-seq kit that allows users to do dual-indexed sequencing. The YourSeq Dual RNAseq Library Kit is a versatile, Illumina-compatible RNAseq library kit that can
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In this work, we describe a novel machine learning method to predict protein binding affinity using protein sequence and structure information. Previously, various machine learning models have been developed for this purpose using standard machine learning approaches using sequence or structure information. Typically, structure-based methods generate better predictions than sequence-based ones but are limited by
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An artistic impression of a sunset from Barnard’s star on a newly detected planet dubbed “Super Earth,” in this handout photo provided November 14, 2018. European Southern Observatory/M. Kornmesser/Handout via REUTERS WASHINGTON (Reuters) – A frozen and dimly lit planet, dubbed a “Super-Earth,” may be orbiting the closest single star to our solar system, astronomers
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By choosing “I agree” below, you agree that NPR’s sites use cookies, similar tracking and storage technologies, and information about the device you use to access our sites to enhance your viewing, listening and user experience, personalize content, personalize messages from NPR’s sponsors, provide social media features, and analyze NPR’s traffic. This information is shared
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Night by night, star by star, astronomers are edging ever closer to learning just how crowded our universe really is—or at least our galaxy, anyway. A quarter century after the first exoplanets were found orbiting other stars, statistics from the thousands now known have revealed that, on average, each and every stellar denizen of the
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Wind farms are popping up all over the world. In the U.S. alone wind power capacity has tripled over the last decade. Although this trend is good news for efforts to curtail emissions and climate change, a growing body of research suggests wind turbines disturb their local environment in a significant way. Scientists have documented,
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Share to facebook Share to twitter Share to linkedin It’s a girl! It’s a boy! It’s a new shark species! The ninja lanternshark (which was covered in an earlier post in October) now has a new relative. Marsha’s lanternshark (Etmopterus marshae) is from the Philippines area and sports splendid green eyes and a slim, dark
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To the Editor Nemes and colleagues (July 12 issue)1 examined the effects of bacille Calmette–Guérin (BCG) revaccination on reducing the rate of sustained QuantiFERON-TB Gold In-tube assay (QFT) conversion among adolescents in a high-risk setting. One aspect that received relatively little attention in the trial regards the immunologic mechanisms responsible for these effects, which were
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To the Editor: Fibrous dysplasia and the McCune–Albright syndrome constitute a rare mosaic disorder caused by somatic activating mutations of Gαs (the G-protein subunit αs). Characteristic manifestations, including café-au-lait skin lesions, fibrous dysplasia of bone, and hyperfunctioning endocrinopathies, occur with varying severity, depending on the embryonic stage at which the mutation occurred. Mutations early in
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A 56-year-old woman presented to the emergency department with shortness of breath that had progressively worsened over 8 months. She had no history of tobacco use. On presentation, the patient received 3 liters of supplemental oxygen to maintain an oxygen saturation of 93%. Findings from a lung examination were notable for bronchial breath sounds in
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To the Editor Post hoc analysis of Sanofi’s Dengvaxia (CYD-TDV) vaccine by Sridhar et al. (July 26 issue)1 provides evidence for an increased risk of severe dengue virus (DENV) disease among DENV-seronegative vaccinees. The authors address the possibility of antibody-dependent enhancement, but T-cell–mediated immunopathology represents another plausible explanation for this clinical outcome. Vaccine efficacy among
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To the Editor The results of the iNNOVATE trial reported by Dimopoulos et al. (June 21 issue)1 showed the improved efficacy of ibrutinib when added to rituximab monotherapy for Waldenström’s macroglobulinemia. This practice-changing, phase 3 trial involved patients with a rare form of lymphoma. Table 1. Table 1. Outcomes and Prices of Common Immunochemotherapeutic Regimens
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To the Editor Gaudino et al. (May 31 issue)1 report a lower risk of the composite of death, myocardial infarction, or repeat revascularization with radial-artery graft than with saphenous-vein graft revascularization during coronary-artery bypass grafting (CABG). We question the appropriateness of this composite: death and myocardial infarction are more serious than repeat revascularization. The authors
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Posted by: RNA-Seq Blog in Splicing and Junction Mapping 5 hours ago 33 Views Next generation sequencing (NGS) technologies enable rapid and cheap genome-wide transcriptome analysis, providing vital information about gene structure, transcript expression and alternative splicing. Key to this is the the accurate identification of exon-exon junctions from RNA sequenced (RNA-Seq) reads. A number
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The nation’s hospitals have been merging at a rapid pace for a decade, forming powerful organizations that influence nearly every health care decision consumers make. The hospitals have argued that consolidation benefits consumers with cheaper prices from coordinated services and other savings. But an analysis conducted for The New York Times shows the opposite to
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Veterans Affairs Secretary Robert Wilkie defended the agency’s ongoing experiments on dogs Friday and said he would continue to “reauthorize” them, eight months after Congress passed legislation limiting tests that are opposed by a bipartisan cast of lawmakers and several veterans’ groups. Speaking at the National Press Club, Wilkie rejected calls to end research that
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inDrop™ System selected to generate predictive multi-omic clinical research data for undiagnosed conditions with immune dysfunction 1CellBio Inc., a leading single-cell analysis company serving the biomedical research community, today announced a partnership agreement with the Open Medicine Institute (OMI), a leading independent precision medicine clinical and research organization. Researchers at OMI will apply and validate
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