Strap yourselves in, because CERN has something up its sleeve. On Thursday 1 November, Large Hadron Collider (LHC) physicists will be discussing the fact that they may have found a new and unexpected new particle. “I’d say theorists are excited and experimentalists are very sceptical,” CERN physicist Alexandre Nikitenko told The Guardian. “As a physicist
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Researchers from the Max Delbrück Center for Molecular Medicine present omniCLIP, a probabilistic approach to identify RBB-RNA interaction sites from CLIP-data. The model presents a principled framework for the analysis of CLIP-Seq assays and takes into account several important new aspects. First, it jointly models the CLIP-Seq and background data in all replicates and accounts for confounding factors
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Neanderthals are often depicted as barrel-chested, hunched-over cavemen, but a close inspection of their fossils is telling a different story. For the first time, an international team of researchers has reconstructed the ribcage and upper spine of a Neanderthal man who died roughly 60,000 years ago. The findings suggest that contrary to popular images, these
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The Iowa State University Veterinary Diagnostic Laboratory The ISU VDL provided IAV diagnostic and sequencing services from 2003 to present, with significant increases in the past 2 years: since 2015, the ISU VDL processed over 1,000 IAV-related cases annually collected from 38 states across the continental US. The IAV diagnostic results and related sequences are stored
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The TASSEL-GBS pipeline modified for polyploids Earlier implementations of TASSEL-GBS (v.3 and 4) output truncated read counts per allele in the VCF file. The most recent version (v.5) of the pipeline addressed this limitation, but provides only approximate values for higher read counts [7]. The read counts are then used for genotype calling [6], which
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The causes of evolvability and their evolution The causes of evolvability and their evolution, Published online: 01 November 2018; doi:10.1038/s41576-018-0069-z In this article, Payne and Wagner discuss how recent experimental studies are complementing theoretical work to enhance our understanding of the evolvability of diverse biological systems. They highlight phenotypic heterogeneity, robustness and adaptive landscape topography
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Genetics research offers both potential benefits and potential harms to under-represented communities. While researchers have been making great strides in the use of genomics for both medical and historical questions, the vast majority of participants in such studies are of European descent.  This is due to several reasons, among them a history of colonialism and exploitation
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Image Want climate news in your inbox? Sign up here for Climate Fwd:, our email newsletter. WASHINGTON — Ryan Zinke, the interior secretary, faces at least a half-dozen ongoing ethics inquiries related to his leadership at the Interior Department. The inquiries include investigations into Mr. Zinke’s personal financial dealings and his handling of policy matters
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Citation: Nöh K, Niedenführ S, Beyß M, Wiechert W (2018) A Pareto approach to resolve the conflict between information gain and experimental costs: Multiple-criteria design of carbon labeling experiments. PLoS Comput Biol 14(10): e1006533. https://doi.org/10.1371/journal.pcbi.1006533 Editor: Vassily Hatzimanikatis, Ecole Polytechnique Fédérale de Lausanne, SWITZERLAND Received: May 16, 2018; Accepted: September 27, 2018; Published: October 31,
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Abstract Effective cancer treatment is crucially dependent on the identification of the biological processes that drive a tumor. However, multiple processes may be active simultaneously in a tumor. Clustering is inherently unsuitable to this task as it assigns a tumor to a single cluster. In addition, the wide availability of multiple data types per tumor
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Abstract Malaria is a life-threatening disease spread by mosquitoes. Plasmodium falciparum M1 alanyl aminopeptidase (PfM1-AAP) is a promising target for the treatment of malaria. The recently solved crystal structures of PfM1-AAP revealed that the buried active site can be accessed through two channel openings: a short N-terminal channel with the length of 8 Å and
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Sebastian Tobler’s doctors thought his legs would never move again after a mountain-biking accident completely paralyzed them. When he signed up for a study at Lausanne University Hospital in Switzerland, Tobler’s injury was so severe that the researchers had doubts their experimental treatment would work. “I was like, should we enroll this participant? It’s very
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“Telemedicine is the natural evolution of healthcare in the digital world,” American Telemedicine Association. Telemedicine empowers the caregivers to remotely interact with their patients, which greatly improves both the efficiency and affordability of healthcare. Today patients, doctors and caregivers have learned to accept telemedicine (often called ‘telehealth’ or ‘connected health’) as one of many ways
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SEATTLE/ORLANDO, Fla. (Reuters) – SpaceX Chief Executive Officer Elon Musk flew to the Seattle area in June for meetings with engineers leading a satellite launch project crucial to his space company’s growth. FILE PHOTO: SpaceX headquarters is shown in Hawthorne, California, U.S. September 19, 2018. REUTERS/Mike Blake/File Photo Within hours of landing, Musk had fired
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Posted by: RNA-Seq Blog in Review Publications 6 hours ago 116 Views Transcriptome profiling has become routine in studies of many biological processes. However, favored approaches such as short-read Illumina RNA sequencing are giving way to long-read sequencing platforms better suited to interrogating the complex transcriptomes typical of many RNA and DNA viruses. Here, researchers
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Just in time for Halloween, astronomers have delivered the best-yet view of a real-life cosmic monster—Sagittarius A*, a supermassive black hole lurking at the center of the Milky Way. Or, rather, a view of hot clumps of gas that orbit it, teetering on the edge of oblivion. The results reveal new, previously unknown properties of
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When experiments are run at CERN’s Large Hadron Collider particle accelerator, it’s a tremendous event. The world’s largest machine has been responsible for discovering numerous new subatomic particles, including the ultra-elusive Higgs boson.  And lately, its data has been hinting tantalisingly at new physics beyond the Standard Model – the best set of equations we
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Analysis for Relapse-Specific Mutations To determine whether AML relapse after transplantation was associated with recurrent mutations, we performed enhanced exome sequencing on samples from 15 patients who had a relapse after transplantation, including 6 patients who presented with isolated extramedullary disease. The transplants had been from HLA-matched related donors, HLA-matched unrelated donors, or HLA-mismatched unrelated
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To the Editor We thank Kao et al. (June 21 issue)1 for their discussion but question the diagnosis of atypical hemolytic–uremic syndrome, a disorder we similarly considered in a 3-year-old girl who presented with anemia (hemoglobin level, 78 g per deciliter), thrombocytopenia (platelet count, 22,000 per cubic millimeter), and azotemia (creatinine level, 1.9 mg per
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A 5-year-old girl presented to the emergency department with a preauricular mass and submandibular adenopathy on the left side of her face that had been visible for 2 months. An excoriation below the left eye (Panel A, red arrow), a fluctuant, tender preauricular mass (Panel A, blue arrow; and Panel B), and submandibular adenopathy (Panel
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Abstract Background The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces tumor-cell phagocytosis. 5F9 synergizes with rituximab to eliminate B-cell non-Hodgkin’s lymphoma cells by enhancing macrophage-mediated antibody-dependent cellular phagocytosis. This combination was evaluated clinically. Methods We conducted a phase 1b study involving patients with relapsed or refractory non-Hodgkin’s lymphoma.
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To the Editor: Several classic cardiac genetic disorders have been identified from specific electrocardiographic (ECG) patterns.1-3 Here, we describe five unrelated families, from three different countries, with features that appear to represent a previously unrecognized autosomal dominant syndrome. These families were identified at three tertiary referral centers for patients with known or suspected inherited cardiac
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The Soyuz rocket is launched with Expedition 57 Flight Engineer Nick Hague of NASA and Flight Engineer Alexey Ovchinin of Roscosmos at the Baikonur Cosmodrome, Kazakhstan October 11, 2018. NASA/Bill Ingalls/Handout via REUTERS MOSCOW (Reuters) – The Soyuz rocket launch failure this month was caused by a faulty sensor, Russian news agencies reported citing an
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Posted by: RNA-Seq Blog in Publications 56 mins ago 35 Views Cancers acquire resistance to systemic treatment with platinum-based chemotherapy (eg, cisplatin [CDDP]) as a result of a dynamic intratumoral heterogeneity (ITH) and clonal repopulation. However, little is known about the influence of chemotherapy on ITH at the single-cell level. Here, mapping the transcriptome of
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