Single-cell RNA-sequencing (scRNA-seq) has brought the study of the transcriptome to higher resolution and makes it possible for scientists to provide answers with more clarity to the question of ‘differential expression’. However, most computational methods still stick with the old mentality of viewing differential expression as a simple ‘up or down’ phenomenon. We advocate that
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Prehistoric humans were sexual adventurers, mating with Neanderthals and Denisovans, but DNA studies reveal dalliances with populations we never knew existed Peter Strain By Catherine Brahic WE LEARN about our ancestors in many ways. Bones tell us what they looked like. Teeth reveal their diet. Tools, pots, art and other artefacts hold stories about their
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If you’re looking for insight into the true you, there’s a buffet of personality questionnaires available. Some are silly—like the internet quiz that tells everyone who takes it that they are procrastinators at the core. Other questionnaires, developed and sold as tools to help people hire the right candidate or find love, take themselves more
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To the Editor We acknowledge that the Early Venous Reflux Ablation (EVRA) trial by Gohel et al. (May 31 issue)1 will undoubtedly play a role in changing management practices for this frequently neglected patient cohort, although we wish to make two points. First, whereas previous studies have suggested that endovenous therapies might be beneficial even
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Spectrum of Genomic Changes in Myeloproliferative Neoplasms Figure 1. Figure 1. Genomic Landscape of Myeloproliferative Neoplasms. Panel A shows the frequency of recurrently mutated genes and chromosomal abnormalities in the cohort of 2035 patients. Mutations were stratified according to type (missense, nonsense, affecting a splice site, or other [e.g., stop, gain, or loss]). Insertions and
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From Réanimation Médicale, Centre Hospitalier Universitaire (CHU) de Nîmes (S.D.B., B. Louart, R.T.), and Saint Eloi, CHU de Montpellier, Université de Montpellier, and INSERM Unité 1046 (S.J.), Service de Réanimation Médicale, CHU Lapeyronie (K.K.), Montpellier, Université de Strasbourg, Faculté de Médecine, Hôpitaux Universitaires de Strasbourg, Service de Réanimation, Nouvel Hôpital Civil, Strasbourg (R.C.-J., F. Meziani,
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To the Editor In their Clinical Practice article, Biondi and Cooper (June 21 issue)1 state that Graves’ disease is a common cause of endogenous subclinical hyperthyroidism, accounting for 40% of cases in populations with adequate iodine intake. The authors cite a review article2 that references original articles reporting a prevalence of Graves’ disease that is
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To the Editor: Figure 1. Figure 1. Growth in Scheduled Video Visits, 2015–2017 (210,383 Total Visits). Video visits could be conducted by all clinicians (including medical doctors, osteopathic physicians, nurse practitioners, and physician assistants), with growing implementation by departments or through individual adoption over time. All the patients were potentially eligible for a video visit.
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The sheer speed with which end-stage liver failure can consume a patient is what makes the disease so devastating.1,2 Unfortunately, Ms. S.’s family had never been informed about that reality. When they brought her in for a mere urinary tract infection, they were shocked that it took only days for her heart, lungs, and immune
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To the Editor I agree with the call of Fernandez Lynch and colleagues (June 21 issue)1 for a collaborative approach to informed consent while maintaining the central roles of the treating doctor and the patient. Rendering informed consent a nondelegable responsibility in the United States could have far-reaching implications if it were to establish a
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To the Editor The analysis of safety trials of long-acting β2-agonists (LABAs) by Busse et al. (June 28 issue)1 concluded that adding a LABA to an inhaled glucocorticoid was safe. However, patients with previous life-threatening reactions were excluded from the analysis. My colleague and I had previously reported on two boys, 10 and 15 years
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long RNAs are first converted into a library of cDNA fragments through either RNA fragmentation or DNA fragmentation. Sequencing adaptors (blue) are subsequently added to each cDNA fragment and a short sequence is obtained from each cDNA using high-throughput sequencing technology. The resulting sequence reads are aligned with the reference genome or transcriptome, and classified
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For millions of people around the globe, antidepressants are vital medications. Unfortunately, once those pharmaceuticals have done their job inside our bodies, their biochemical effects don’t stop there. Two researchers from the University of Portsmouth are calling for greater awareness of the risks posed by our prescriptions once they’ve been flushed into the environment, in
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The phylogenomics of evolving virus virulence The phylogenomics of evolving virus virulence, Published online: 10 October 2018; doi:10.1038/s41576-018-0055-5 The virulence of viruses is a major determinant of the health burden of viral infections in humans and other species. In this article, Geoghegan and Holmes discuss how largely disparate research fields — theoretical modelling of virulence
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Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing, Published online: 10 October 2018; doi:10.1038/s41583-018-0068-2 Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual
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Lovelace also studied mesmerism and phrenology, two fields which have since been discredited.Alfred Edward Chalon The second Tuesday in October is Ada Lovelace Day, a day to celebrate and encourage the accomplishments of women in science, technology, and engineering. But who was Ada Lovelace? She wrote the first computer program and was the first to imagine
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A drone pilot working for Hummingbird scans a farmer’s field.Photo via Hummingbird Technologies For thousands of years, farming involved making judgments about water, fertilizers or new seeds with the human eye. Today farmers are using machine-learning tools to boost their yields and help their bottom line.  One London-based agtech startup has spent the past two
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(Reuters) – Johnson & Johnson said on Tuesday its blockbuster drug Stelara was found to be effective in treating a chronic bowel disease in a late-stage trial. FILE PHOTO: A Johnson & Johnson building is shown in Irvine, California, U.S., January 24, 2017. REUTERS/Mike Blake/File Photo Two doses of Stelara, already approved for psoriasis, psoriatic
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Posted by: RNA-Seq Blog in Databases, Publications 7 hours ago 117 Views Rice (Oryza sativa) is one of the most important worldwide crops. The genome has been available for over 10 years and has undergone several rounds of annotation. University of Liverpool researchers created a comprehensive database of transcripts from 29 public RNA sequencing datasets,
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Leaked documentation reveals new Macs contain a hidden mechanism designed to make them inoperative if they are independently repaired, reports show. According to technical memos obtained by a number of outlets, any Mac with Apple’s new T2 chip conceals a security feature critics describe as a ‘kill switch’, which effectively bricks the devices if they
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The importance of RNA methylation in biological processes is an emerging focus of investigation. University of Texas Health Science Center at San Antonio researchers report that altering m6A levels by silencing either N6-adenosine methyltransferase METTL14 (methyltransferase-like 14) or demethylase ALKBH5 (ALKB homolog 5) inhibits cancer growth and invasion. METTL14/ALKBH5 mediate their protumorigenic function by regulating
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sciencetake What a Frog Needs to Make That Leap Video A frog’s leap is a study in power and accuracy. So how do frogs do it, and what can humans learn from its mechanics?Published OnOct. 9, 2018 By James Gorman Oct. 9, 2018 Frogs are terrific jumpers. Ask any child who has tried to catch
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New U.N. Climate Report Says Put a High Price on Carbon Image The Tesoro Los Angeles oil refinery in California. Economists have long been enthusiastic about carbon pricing because of the idea’s simplicity.CreditCreditLucy Nicholson/Reuters By Brad Plumer Oct. 8, 2018 WASHINGTON — In its landmark report on the fast-approaching dangers of climate change, a United Nations
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Your Dog May Be Smart, but She’s Not Exceptional Image Douglas Moreira, a dog walker, and his charges in Central Park this summer. A new study on dog intelligence says they are smart, but not “exceptional.”CreditCreditEmma Howells/The New York Times By Laura M. Holson Oct. 8, 2018 Cat lovers of the world rejoice! In the
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