Receptor replacement Receptor replacement, Published online: 12 September 2018; doi:10.1038/s41583-018-0060-x Mice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.
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T cells under starter’s orders T cells under starter’s orders, Published online: 11 September 2018; doi:10.1038/s41577-018-0067-6 Naive CD4+ T cells are prepared for rapid activation and metabolic remodelling through the derepression of a poised translational machinery, which occurs independently of nutrient-sensing pathways.
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Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need, Published online: 11 September 2018; doi:10.1038/s41579-018-0085-1 Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
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Inflammasome signalling in brain function and neurodegenerative disease Inflammasome signalling in brain function and neurodegenerative disease, Published online: 11 September 2018; doi:10.1038/s41583-018-0055-7 Inflammasomes are pro-inflammatory protein complexes that become activated in a range of neurodegenerative conditions. In this review, Heneka and colleagues discuss recent findings that provide fresh insights on the role of inflammasomes across
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Microglial signatures and their role in health and disease Microglial signatures and their role in health and disease, Published online: 11 September 2018; doi:10.1038/s41583-018-0057-5 Technological advances have allowed the molecular ‘signatures’ of microglia to be characterized, providing insight into their roles in CNS function. Weiner and Butovsky discuss the plasticity of these signatures in health
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Three-photon imaging of mouse brain structure and function through the intact skull Three-photon imaging of mouse brain structure and function through the intact skull, Published online: 10 September 2018; doi:10.1038/s41592-018-0115-y Wang et al. demonstrate that the effects of aberrations and scattering caused by the mouse skull can be reduced with three-photon microscopy. Their approach allows
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COMRADES determines in vivo RNA structures and interactions COMRADES determines in vivo RNA structures and interactions, Published online: 10 September 2018; doi:10.1038/s41592-018-0121-0 In vivo probing of RNA structures with COMRADES yields insight into RNA folding of the ZIKA virus genome and its interaction with host RNAs.
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Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms Terminal exon characterization with TECtool reveals an abundance of cell-specific isoforms, Published online: 10 September 2018; doi:10.1038/s41592-018-0114-z TECtool identifies terminal exons from RNA-seq data, uncovering novel isoforms, many of which are translated.
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Elon Musk smoking a spliff on the Joe Rogan show.YouTube/PowerfulJRE Tesla billionaire Elon Musk smoked marijuana and discussed “cybernetic collectives” with California comedian Joe Rogan during a live interview on Friday. During the 2-hour 37-minute podcast interview, Musk sampled a spliff containing marijuana and tobacco, saying “it’s legal, right?” The pair discussed a wide range of topics
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Abstract Distribution networks—from vasculature to urban transportation pathways—are spatially embedded networks that must route resources efficiently in the face of pressures induced by the costs of building and maintaining network infrastructure. Such requirements are thought to constrain the topological and spatial organization of these systems, but at the same time, different kinds of distribution networks
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Abstract Mutational correlation patterns found in population-level sequence data for the Human Immunodeficiency Virus (HIV) and the Hepatitis C Virus (HCV) have been demonstrated to be informative of viral fitness. Such patterns can be seen as footprints of the intrinsic functional constraints placed on viral evolution under diverse selective pressures. Here, considering multiple HIV and
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Atlanta Falcons Pro Bowl safety Keanu Neal will miss the rest of the season after tearing the anterior cruciate ligament in his left knee during Thursday’s season-opening loss to the Philadelphia Eagles, the team announced. Apr 28, 2016; Chicago, IL, USA; Keanu Neal (Florida) is selected by the Atlanta Falcons as the number seventeen overall
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Posted by: RNA-Seq Blog in Publications 1 hour ago 70 Views Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell RNA-sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Here, researchers from Massachusetts General Hospital and Harvard Medical School show that intercellular heterogeneity
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Feedback is our weekly column of bizarre stories, implausible advertising claims, confusing instructions and more Paul McDevitt High office A CONGRESSIONAL candidate in Florida who claims to have been abducted by aliens says she doesn’t want to be defined by the experience. City councillor Bettina Rodriguez Aguilera claims that blond, Christ-like aliens took her aboard
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A Roswell Park-led research team has linked the development of castration-resistant prostate cancer and resistance to treatment to a lack of androgen receptor expression in prostate cancer cells, identifying a new therapeutic target.  A collaborative research team has linked the development of castration-resistant prostate cancer and resistance to treatment to a lack of androgen receptor
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This is the only detailed whole-planet image we have of Neptune, as taken by Voyager 2’s narrow angle camera in 1989NASA/JPL If you want to see Neptune and you can get yourself to a telescope, tonight’s the night. We have only one decent photo of Neptune, the furthest planet from the Sun. It was taken
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One of the world’s deadliest spiders is among the thousands of bugs and reptiles that were recently stolen from the Philadelphia Insectarium and Butterfly Pavilion, according to authorities. Security cameras caught several people leaving the museum on August 22 with 80 to 90 percent of the collection housed in plastic containers, from tarantulas to geckos.
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Illinois sophomore quarterback Cam Thomas has departed the program just 10 days after failing to win the starting position. Sep 1, 2018; Miami, FL, USA; FIU Golden Panthers running back Anthony Jones (2) carries the ball in the first quarter against the Indiana Hoosiers at Riccardo Silva Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports Illinois
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Rewiring urea cycle metabolism in cancer to support anabolism Rewiring urea cycle metabolism in cancer to support anabolism, Published online: 07 September 2018; doi:10.1038/s41568-018-0054-z This Review discusses the reprogramming of the urea cycle, the main metabolic liver pathway for nitrogen disposal, in cancer cells. The authors provide insight into the metabolic advantages and therapeutic opportunities stemming from
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The birth, evolution and death of metabolic gene clusters in fungi The birth, evolution and death of metabolic gene clusters in fungi, Published online: 07 September 2018; doi:10.1038/s41579-018-0075-3 In this Review, Rokas, Wisecaver and Lind discuss the diversity in the structure and content of fungal metabolic gene clusters, their population-level and species-level variation, the evolutionary
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To degrade or not to degrade: mechanisms and significance of endocytic recycling To degrade or not to degrade: mechanisms and significance of endocytic recycling, Published online: 07 September 2018; doi:10.1038/s41580-018-0053-7 Endocytosed membrane proteins can either be degraded in the lysosome or recycled back to the membrane. This decision, which has an impact on protein levels,
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Rodent models for Alzheimer disease Rodent models for Alzheimer disease, Published online: 07 September 2018; doi:10.1038/s41583-018-0054-8 Rodent models are extensively used to investigate the pathophysiology of Alzheimer disease. In this Review, Götz, Bodea and Goedert critically examine the approaches that have been adopted to generate rodent Alzheimer disease models and touch on some of the
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An RNA toolbox for cancer immunotherapy An RNA toolbox for cancer immunotherapy, Published online: 07 September 2018; doi:10.1038/nrd.2018.132 In this Review, Pastor et al. provide an overview of RNA-based agents used in cancer immunotherapy — ranging from RNA vaccines encoding cancer neoantigens to interference RNAs and protein-binding RNA aptamers — providing insights into this emerging
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Even if the team enters the season without its All-Pro running back, the Pittsburgh Steelers are not planning to change their position in the ongoing standoff with Le’Veon Bell. Jan 14, 2018; Pittsburgh, PA, USA; Pittsburgh Steelers running back Le’Veon Bell (26) celebrates after catching a touchdown pass against the Jacksonville Jaguars during the third
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This train features a 3D-printed housing cover.Stratasys Advances in 3D-printing have been hyped in a number of futuristic applications, like cutting-edge applications in airplane design or parts of rocket engines. But 3D-printing is also making strides in railroads, which hasn’t been considered new-fangled since the 19th century.  In fact, replacement parts printed by Stratasys industrial
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Abstract Oscillatory activity robustly correlates with task demands during many cognitive tasks. However, not only are the network mechanisms underlying the generation of these rhythms poorly understood, but it is also still unknown to what extent they may play a functional role, as opposed to being a mere epiphenomenon. Here we study the mechanisms underlying
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