A changing paradigm of transcriptional memory propagation through mitosis

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A changing paradigm of transcriptional memory propagation through mitosis

A changing paradigm of transcriptional memory propagation through mitosis, Published online: 12 November 2018; doi:10.1038/s41580-018-0077-z

Recent data indicate that various transcription factors and RNA polymerase II bind to mitotic chromatin and that thousands of genes remain transcriptionally active in mitosis, contradicting the view that mitotic cells are transcriptionally silenced. These mechanisms provide mitotic transcriptional memory, which allows re-establishment of cell-type-specific gene expression following division.

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