Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

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Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

Central CD4<sup>+</sup> T cell tolerance: deletion versus regulatory T cell differentiation, Published online: 12 November 2018; doi:10.1038/s41577-018-0083-6

Self-antigen recognition in the thymus can result in both clonal deletion of developing thymocytes and their diversion into the regulatory T cell lineage. How do thymocyte-intrinsic and thymocyte-extrinsic determinants influence this cell fate choice?

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