Clinical epigenetics: seizing opportunities for translation
Clinical epigenetics: seizing opportunities for translation, Published online: 27 November 2018; doi:10.1038/s41576-018-0074-2
Disruptions to the epigenome occur during the pathogenesis of various human diseases. In this Review, Berdasco and Esteller describe the challenges and progress of harnessing epigenetic changes for clinical application, including for diagnostics, disease classification and therapeutics. They discuss applications to diverse diseases, such as cancer, neurological disease, immune disorders and viral infections.