Integrative regulation of physiology by histone deacetylase 3

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Integrative regulation of physiology by histone deacetylase 3

Integrative regulation of physiology by histone deacetylase 3, Published online: 02 November 2018; doi:10.1038/s41580-018-0076-0

The activity of many cell type-specific enhancers is regulated by histone deacetylase 3 (HDAC3), which acts in complex with various nuclear receptor co-repressors. HDAC3 is required for many aspects of mammalian development and physiology, including the metabolism of various organs, neuronal- and haematopoietic stem cell fate and function, lung and bone development and intestinal homeostasis.

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