Organizational principles of 3D genome architecture


Organizational principles of 3D genome architecture

Organizational principles of 3D genome architecture, Published online: 26 October 2018; doi:10.1038/s41576-018-0060-8

High-resolution studies of chromosome conformation are revealing that the 3D genome is organized into smaller structural features than was previously supposed and is primarily composed of compartmental domains and CTCF loops. In this Perspectives article Rowley and Corces describe the latest views on the organizational drivers and principles of the 3D genome, and the interplay between genome activity and organization.

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