Polymer–drug conjugate therapeutics: advances, insights and prospects

Reviews

Polymer–drug conjugate therapeutics: advances, insights and prospects

Polymer–drug conjugate therapeutics: advances, insights and prospects, Published online: 12 December 2018; doi:10.1038/s41573-018-0005-0

The conjugation of therapeutic agents to polymer carriers, such as polyethylene glycol (PEG), can control drug delivery, enhance solubilization, increase efficacy and improve pharmacokinetics. Here, Grinstaff, Colson and Ekladious discuss recent advances in the preclinical and clinical development of different classes of polymer–drug conjugates and highlight current challenges and future directions.

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