A model for RAS mutation patterns in cancers: finding the sweet spot

A model for RAS mutation patterns in cancers: finding the sweet spot

A model for RAS mutation patterns in cancers: finding the sweet spot, Published online: 12 November 2018; doi:10.1038/s41568-018-0076-6

In this Opinion, Li et al. put forward the idea that there is a narrow window or ‘sweet spot’ in which oncogenic RAS signalling can promote tumour initiation in normal cells and present the evidence that RAS mutation patterns are the product of selection for optimal RAS mutations to achieve the ideal level of signalling.

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