Base editing: precision chemistry on the genome and transcriptome of living cells

Base editing: precision chemistry on the genome and transcriptome of living cells

Base editing: precision chemistry on the genome and transcriptome of living cells, Published online: 15 October 2018; doi:10.1038/s41576-018-0059-1

Genome editing through direct editing of bases holds promise for achieving precise genomic changes at single-nucleotide resolution while minimizing the occurrence of potentially mutagenic double-strand DNA breaks. In this Review, Rees and Liu provide a comprehensive account of the state of the art of base editing of DNA and RNA, including the progressive improvements to methodologies, understanding and avoiding unintended edits, cellular and organismal delivery of editing reagents and diverse applications in research and therapeutic settings.

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