Functions and mechanisms of epigenetic inheritance in animals

Functions and mechanisms of epigenetic inheritance in animals

Functions and mechanisms of epigenetic inheritance in animals, Published online: 13 November 2018; doi:10.1038/s41580-018-0074-2

Epigenetic profiling of germline and zygotic genomes has revealed that a fraction of mammalian genomes do not undergo epigenetic reprogramming during early development, highlighting the importance of epigenetic inheritance in animals. Inheritance of histone modifications, tRNA fragments and microRNAs can affect gene regulation in the offspring; however, in mammals, epigenetic inheritance rarely operates beyond two generations.

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