Genomic evolution of cancer models: perils and opportunities

Genomic evolution of cancer models: perils and opportunities

Genomic evolution of cancer models: perils and opportunities, Published online: 21 December 2018; doi:10.1038/s41568-018-0095-3

Genomic instability in cancer models presents a major challenge in the design and reproducibility of research and its clinical translation. This Opinion article discusses the causes and consequences of intra-tumour genomic heterogeneity and instability in commonly used models and implications thereof.

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