Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine, Published online: 13 December 2018; doi:10.1038/s41580-018-0086-y
The Hippo pathway effectors YAP and TAZ regulate normal and tumorigenic organ growth. Recent studies in vitro and in mouse models have shown that these two transcription co-activators can also promote tissue regeneration. This property could be exploited for regenerative medicine, as long as the therapeutic approaches can minimize the potential for cancer development.