Host and viral determinants of influenza A virus species specificity

Host and viral determinants of influenza A virus species specificity

Host and viral determinants of influenza A virus species specificity, Published online: 28 November 2018; doi:10.1038/s41579-018-0115-z

Influenza A viruses cause pandemics when they cross between species. In this Review, Barclay and colleagues examine the host barriers that influenza A viruses must overcome to initiate a pandemic in humans and describe how, on crossing the species barrier, the virus mutates to establish new interactions with the human host.

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