Medications With Depression as an Adverse Effect

In Reply Drs Agustini and Berk raise 3 primary concerns regarding our analysis demonstrating an association between the use of prescription medications with depression as a potential adverse effect and concurrent depression.

Their first concern is that we did not account for the association between depression and other health conditions besides hypertension—particularly conditions related to inflammation, such as pain and asthma, which are often treated with medications, such as pain killers and antihistamines that are associated with depressive symptoms. However, not all commonly used medications to treat these conditions, including hypertension, are associated with an increased risk of depressive symptoms. Specifically, many of the most frequently used nonsteroidal anti-inflammatory drugs (eg, ibuprofen), antihistamines (eg, cetirizine), and proton pump inhibitors (eg, omeprazole and esomeprazole) were on our list of prescription medications with depression as a potential adverse effect, although some nonsteroidal anti-inflammatory drugs (eg, naproxen), antihistamines (eg, loratadine), and proton pump inhibitors (eg, pantoprazole) were not.

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