Mitochondrial proteins: from biogenesis to functional networks

Mitochondrial proteins: from biogenesis to functional networks

Mitochondrial proteins: from biogenesis to functional networks, Published online: 09 January 2019; doi:10.1038/s41580-018-0092-0

Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization and interactions. This Review discusses how the mitochondrial protein import machinery functions as a key organizer of these protein networks, its involvement in the formation of membrane contact sites, and how defects in protein import can lead to disease.

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