New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer, Published online: 20 November 2018; doi:10.1038/s41580-018-0080-4

Epithelial–mesenchymal transition (EMT) is crucial for embryogenesis, wound healing and cancer development, and confers greater resistance to cancer therapies. This Review discusses the mechanisms of EMT and its roles in normal and neoplastic tissues, the contribution of cell-intrinsic signals and the microenvironment to inducing EMT, and its effects on the immunobiology of carcinomas.

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