PIWI-interacting RNAs: small RNAs with big functions

PIWI-interacting RNAs: small RNAs with big functions

PIWI-interacting RNAs: small RNAs with big functions, Published online: 16 November 2018; doi:10.1038/s41576-018-0073-3

PIWI-interacting RNAs (piRNAs) have numerous crucial biological roles, particularly transposon silencing in the germ line. In this Review, the authors describe our latest understanding of piRNA biogenesis and functions across diverse species, highlighting how, despite the universal importance of transposon control, different species have evolved intriguingly distinct mechanistic routes to achieve this.

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