Stem cell fate in cancer growth, progression and therapy resistance

Stem cell fate in cancer growth, progression and therapy resistance

Stem cell fate in cancer growth, progression and therapy resistance, Published online: 18 September 2018; doi:10.1038/s41568-018-0056-x

This Review discusses how cells with stem cell characteristics often serve as the tumour cell of origin, as they are preferentially primed for transformation. Furthermore, the activation of stem cell programmes can be crucial for promoting cancer progression and therapy resistance.

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